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Correspondence
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Volume 345:1063-1064 October 4, 2001 Number 14
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A Gene Responsible for Familial Wolff–Parkinson–White Syndrome

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To the Editor: Accurate identification of phenotype is critical for precise genetic characterization. Standard textbooks define the Wolff–Parkinson–White syndrome as the combination of a short PR interval, an increased duration of the QRS complex caused by an initial slow deflection (delta wave), and supraventricular tachyarrhythmias.1,2 The phenotype identified by Gollob et al. (June 14 issue)3 is based on "a short PR interval (<120 msec) with a widened QRS complex (>110 msec) or an abnormal initial QRS vector (a delta wave)." Failure to specify that the widened QRS complex must be due to the slow initial delta wave and failure to . . . [Full Text of this Article]

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