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Correspondence
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Volume 345:1066-1067 October 4, 2001 Number 14
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Hemophilia

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To the Editor: In their review, Mannucci and Tuddenham (June 7 issue)1 discuss the use of recombinant clotting factors for the treatment of hemophilia. When these products were introduced, it was anticipated that there would be an inexhaustible supply of the "safe" factors. Scientific and lay leaders of the National Hemophilia Foundation and the World Federation of Hemophilia heralded these products as optimal therapy.

Because it has long been known that viral diseases may be transmitted from person to person, human-derived blood products have been considered to be less than perfectly safe. Since the introduction of viral-inactivated human-derived products, however, . . . [Full Text of this Article]

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