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Correspondence
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Volume 345:1131-1132 October 11, 2001 Number 15
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Amyotrophic Lateral Sclerosis

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To the Editor: In their review of amyotrophic lateral sclerosis (ALS) Rowland and Shneider (May 31 issue)1 state that "the selective vulnerability of motor neurons" to glutamate may be explained by "the fact that the expression of GluR2 in motor neurons is normally lower than in other neurons." However, there is currently no convincing evidence that the expression of GluR2 is lower in motor neurons than in less vulnerable neurons. More than 10 groups have reported on qualitative studies of the distribution of GluR2 in the spinal cord. With the exception of the group cited by the authors, all the . . . [Full Text of this Article]

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