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Previous Volume 345:1184-1192 October 18, 2001 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Tourette's syndrome is a neurologic disorder named after the French neurologist Georges Gilles de la Tourette, who, in 1885, described nine patients with childhood-onset tics, accompanied in some by uncontrollable noises and utterances, as well as features that are now associated with attention-deficit–hyperactivity disorder, obsessive–compulsive disorder, poor impulse control, and other coexisting behavioral problems.^1,2,3 Although Tourette considered the disorder he described to be hereditary, it was ascribed to psychogenic causes for nearly a century after the original report. The perception of Tourette's syndrome as a rare, bizarre psychological disorder began to change in the 1960s, when the beneficial effects of . . . [Full Text of this Article]

Diagnosis

Pathogenesis

Neuroimaging

Neurophysiology

Neurochemistry

Genetics

Immunology

Epidemiology

Treatment

Treatment of Tics

Treatment of Coexisting Behavioral Symptoms

            Attention-Deficit–Hyperactivity Disorder

            Obsessive–Compulsive Disorder

Conclusions

Source Information

From the Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, 6550 Fannin, Suite 1801, Houston, TX 77030, where reprint requests should be addressed to Dr. Jankovic.

References

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• Worbe, Y., Baup, N., Grabli, D., Chaigneau, M., Mounayar, S., McCairn, K., Feger, J., Tremblay, L. (2009). Behavioral and Movement Disorders Induced by Local Inhibitory Dysfunction in Primate Striatum. Cereb Cortex 19: 1844-1856 [Abstract] [Full Text]  
• Welter, M.-L., Mallet, L., Houeto, J.-L., Karachi, C., Czernecki, V., Cornu, P., Navarro, S., Pidoux, B., Dormont, D., Bardinet, E., Yelnik, J., Damier, P., Agid, Y. (2008). Internal Pallidal and Thalamic Stimulation in Patients With Tourette Syndrome. Arch Neurol 65: 952-957 [Abstract] [Full Text]  
• Ashoori, A, Jankovic, J (2008). Mozart's movements and behaviour: a case of Tourette's syndrome?. Postgrad. Med. J. 84: 313-317 [Abstract] [Full Text]  
• Simpson, D. M., Blitzer, A., Brashear, A., Comella, C., Dubinsky, R., Hallett, M., Jankovic, J., Karp, B., Ludlow, C. L., Miyasaki, J. M., Naumann, M., So, Y. (2008). Assessment: Botulinum neurotoxin for the treatment of movement disorders (an evidence-based review): Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 70: 1699-1706 [Abstract] [Full Text]  
• Ondo, W. G., Jong, D., Davis, A. (2008). Comparison of Weight Gain in Treatments for Tourette Syndrome: Tetrabenazine Versus Neuroleptic Drugs. J Child Neurol 23: 435-437 [Abstract]  
• McCracken, C. B., Grace, A. A. (2007). High-Frequency Deep Brain Stimulation of the Nucleus Accumbens Region Suppresses Neuronal Activity and Selectively Modulates Afferent Drive in Rat Orbitofrontal Cortex In Vivo. J. Neurosci. 27: 12601-12610 [Abstract] [Full Text]  
• Ashoori, A., Jankovic, J. (2007). Mozart's movements and behaviour: a case of Tourette's syndrome?. J. Neurol. Neurosurg. Psychiatry 78: 1171-1175 [Abstract] [Full Text]  
• Shahed, J., Poysky, J., Kenney, C., Simpson, R., Jankovic, J. (2007). GPi deep brain stimulation for Tourette syndrome improves tics and psychiatric comorbidities. Neurology 68: 159-160 [Full Text]  
• Ashwood, P., Wills, S., Van de Water, J. (2006). The immune response in autism: a new frontier for autism research. J. Leukoc. Biol. 80: 1-15 [Abstract] [Full Text]  
• Sedel, F., Friderici, K., Nummy, K., Caillaud, C., Chabli, A., Durr, A., Lubetzki, C., Agid, Y. (2006). Atypical Gilles de la Tourette Syndrome With {beta}-Mannosidase Deficiency. Arch Neurol 63: 129-131 [Abstract] [Full Text]  
• Irwin, R. S., Glomb, W. B., Chang, A. B. (2006). Habit Cough, Tic Cough, and Psychogenic Cough in Adult and Pediatric Populations: ACCP Evidence-Based Clinical Practice Guidelines. Chest 129: 174S-179S [Abstract] [Full Text]  
• Prakash, U. B.S. (2006). Uncommon Causes of Cough: ACCP Evidence-Based Clinical Practice Guidelines. Chest 129: 206S-219S [Abstract] [Full Text]  
• Paulsen, J. S., Nehl, C., Hoth, K. F., Kanz, J. E., Benjamin, M., Conybeare, R., McDowell, B., Turner, B. (2005). Depression and Stages of Huntington's Disease. J. Neuropsychiatry Clin. Neurosi. 17: 496-502 [Abstract] [Full Text]  
• Houeto, J L, Karachi, C, Mallet, L, Pillon, B, Yelnik, J, Mesnage, V, Welter, M L, Navarro, S, Pelissolo, A, Damier, P, Pidoux, B, Dormont, D, Cornu, P, Agid, Y (2005). Tourette's syndrome and deep brain stimulation. J. Neurol. Neurosurg. Psychiatry 76: 992-995 [Abstract] [Full Text]  
• Nevet, A., Morris, G., Saban, G., Fainstein, N., Bergman, H. (2004). Discharge Rate of Substantia Nigra Pars Reticulata Neurons Is Reduced In Non-Parkinsonian Monkeys With Apomorphine-Induced Orofacial Dyskinesia. J. Neurophysiol. 92: 1973-1981 [Abstract] [Full Text]  
• Grabli, D., McCairn, K., Hirsch, E. C., Agid, Y., Feger, J., Francois, C., Tremblay, L. (2004). Behavioural disorders induced by external globus pallidus dysfunction in primates: I. Behavioural study. Brain 127: 2039-2054 [Abstract] [Full Text]  
• Francois, C., Grabli, D., McCairn, K., Jan, C., Karachi, C., Hirsch, E.-C., Feger, J., Tremblay, L. (2004). Behavioural disorders induced by external globus pallidus dysfunction in primates II. Anatomical study. Brain 127: 2055-2070 [Abstract] [Full Text]  
• Jankovic, J (2004). Botulinum toxin in clinical practice. J. Neurol. Neurosurg. Psychiatry 75: 951-957 [Abstract] [Full Text]  
• Lim, S., Rezai, K. A., Abrams, G. W., Eliott, D. (2004). Self-induced, Bilateral Retinal Detachment in Tourette Syndrome. Arch Ophthalmol 122: 930-931 [Full Text]  
• Kwak, C., Vuong, K. D., Jankovic, J. (2003). Migraine Headache in Patients With Tourette Syndrome. Arch Neurol 60: 1595-1598 [Abstract] [Full Text]  
• Teixeira, A L, Cardoso, F, Maia, D P, Cunningham, M C (2003). Sydenham's chorea may be a risk factor for drug induced parkinsonism. J. Neurol. Neurosurg. Psychiatry 74: 1350-1351 [Full Text]  
• Albin, R.L., Koeppe, R.A., Bohnen, N.I., Nichols, T.E., Meyer, P., Wernette, K., Minoshima, S., Kilbourn, M.R., Frey, K.A. (2003). Increased ventral striatal monoaminergic innervation in Tourette syndrome. Neurology 61: 310-315 [Abstract] [Full Text]  
• Church, A J, Dale, R C, Lees, A J, Giovannoni, G, Robertson, M M (2003). Tourette's syndrome: a cross sectional study to examine the PANDAS hypothesis. J. Neurol. Neurosurg. Psychiatry 74: 602-607 [Abstract] [Full Text]  
• Rosa, A. L., Jankovic, J., Ashizawa, T. (2003). Screening for Mutations in the MECP2 (Rett Syndrome) Gene in Gilles de la Tourette Syndrome. Arch Neurol 60: 502-503 [Full Text]  
• Lana-Peixoto, M A, Teixeira, A L, The Brazilian Committee for Treatment and Research, (2002). Simple phonic tic in multiple sclerosis. Mult Scler 8: 510-511 [Abstract]  
• Goetz, C. G., Hinson, V. K. (2002). Therapies for Movement Disorders. Arch Neurol 59: 699-702 [Full Text]  
• DeVeaugh-Geiss, J., Gewurz, A., Jankovic, J. (2002). Tourette's Syndrome. NEJM 346: 710-710 [Full Text]