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Previous Volume 345:1212-1213 October 18, 2001 Number 16 Next

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To the Editor: Rogan et al. (May 10 issue)¹ conclude that chelation therapy with succimer for children with lead levels of 20 to 44 µg per deciliter is valueless. However, an important methodologic weakness of their study is that succimer therapy failed to achieve a timely, enduring reduction in the lead level, producing a difference in blood lead levels between treatment groups of only 2.7 µg per deciliter over a one-year period. There is no evidence (e.g., measurement of erythrocyte protoporphyrin) that succimer effected any significant reduction in the body burden of lead. The authors assert without reference that there . . . [Full Text of this Article]

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