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Previous Volume 345:1345-1346 November 1, 2001 Number 18 Next

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One hundred years ago, type 2 diabetes mellitus was considered a rare disease, but recently there has been an explosive increase in its incidence. About 16 million Americans have type 2 diabetes,¹ and at least an equal number have impaired glucose tolerance. Insulin resistance and hyperinsulinemia are characteristics of both type 2 diabetes and impaired glucose tolerance. These metabolic derangements, combined with the hypertension and dyslipidemia that are common in type 2 diabetes and impaired glucose tolerance, markedly increase the risk of cardiovascular, peripheral vascular, and cerebrovascular disease.

Why has the incidence of type 2 diabetes increased so rapidly? Considerable . . . [Full Text of this Article]

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