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Correspondence
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Volume 345:1424-1425 November 8, 2001 Number 19
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Treatment of Patients with Persistent Symptoms and a History of Lyme Disease

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To the Editor: The study reported by Klempner et al. (July 12 issue)1 showed that patients with chronic Lyme disease are ill; it also showed that the antibiotics used (intravenous ceftriaxone for one month, followed by oral doxycycline for two months) did not lead to improvement. The study did not answer the question of whether better outcomes would have resulted from a longer duration of either intravenous ceftriaxone or oral doxycycline therapy or from treatment with different antibiotics for the same or a longer period. The assumption that ceftriaxone and doxycycline are equivalent and additive treatments for chronic Lyme disease . . . [Full Text of this Article]

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