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Previous Volume 345:115-125 July 12, 2001 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Since its original description nearly 25 years ago,¹ Lyme disease has become recognized as an important infectious disease in the United States. The infection, which is caused by the tick-borne spirochete Borrelia burgdorferi, is now endemic in more than 15 states and has been responsible for focal outbreaks in some eastern coastal areas. Lyme borreliosis is also endemic in Europe and Asia, where certain aspects of the disease (erythema migrans, meningopolyneuritis, and acrodermatitis chronica atrophicans) were described in the early and mid-20th century. These syndromes were linked conclusively in 1982 and 1983 with the recovery of a previously unrecognized spirochete . . . [Full Text of this Article]

Epidemiology and Vector of Transmission

Causation

Clinical Manifestations and Pathogenesis

Skin Involvement and Early Disseminated Infection

Neurologic Involvement

Cardiac Involvement

Joint Involvement

Diagnosis

Treatment and Outcome

Prevention

Source Information

From the Division of Rheumatology and Immunology, Tufts University School of Medicine, Boston.

Because of its potential importance in the treatment of Lyme disease, this article was published at www.nejm.org on June 12, 2001.

Address reprint requests to Dr. Steere at the Division of Rheumatology and Immunology, New England Medical Center #406, 750 Washington St., Boston, MA 02111.

References

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