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Correspondence
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Volume 345:149-150 July 12, 2001 Number 2
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Paternal and Maternal Components of the Predisposition to Preeclampsia

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To the Editor: Esplin and colleagues (March 22 issue)1 found evidence of both paternal and maternal components of the predisposition to preeclampsia. However, their methods raise some issues of concern. First, this association was adjusted for 15 possible confounding variables. Nevertheless, several maternal factors well known to be associated with preeclampsia, such as body-mass index before pregnancy,2 cigarette smoking,3 a change of partner,4 a history of preeclampsia in multiparous women,5 and type of birth (single or multiple),2 were not taken into account as confounding variables. The authors should demonstrate that the inclusion of these factors in the logistic-regression models would . . . [Full Text of this Article]

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