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Previous Volume 345:1458-1463 November 15, 2001 Number 20 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Secondary cancer is a well-established long-term complication of bone marrow transplantation.^1,2,3 These post-transplantation cancers are usually associated with exposure to radiation, other genotoxic agents, or Epstein–Barr virus; in rare cases, they result from the transfer of neoplastic cells in transplanted tissue.⁴

We describe two sisters, one the donor and the other the recipient of a bone marrow transplant, in whom subcutaneous panniculitic T-cell lymphoma^5,6 developed three years after the procedure. The finding of identical T-cell clones in the tumors of both sisters implicated the transfer of neoplastic T cells during bone marrow transplantation as the cause of the recipient's subcutaneous . . . [Full Text of this Article]

Case Reports

Methods

Specimen Collection, Histochemical Analysis, and Isolation of DNA

PCR for TCR Gene Rearrangements

Microsatellite Analysis

Tumor-Specific PCR Analysis

Results

The Size of the Rearranged TCR Genes

Microsatellite Analysis

Sequences of the Rearranged TCR Genes

PCR Analysis of Blood Cells before and after Transplantation

Discussion

Source Information

From the Departments of Pathology (K.D.B., K.M.H., M.G.G., K.M.M., C.A.G., L.S.R.-V., M.J.B., J.R.E.), Dermatology (N.K.B., K.M.H., H.C.N.), Medicine (M.G.G.), and Oncology (K.D.B., M.G.G., R.J.J., C.A.G., L.S.R.-V., J.R.E.), Johns Hopkins School of Medicine, Baltimore; and the Department of Hematology and Oncology, Geisinger Medical Center, Danville, Pa. (A.M.).

Address reprint requests to Dr. Eshleman at the Department of Pathology, 632 Ross Bldg., 720 Rutland Ave., Baltimore, MD 21205, or at jeshlema@jhmi.edu.

References

This article has been cited by other articles:

• Gniadecki, R. (2004). Neoplastic Stem Cells in Cutaneous Lymphomas: Evidence and Clinical Implications. Arch Dermatol 140: 1156-1160 [Full Text]  
• Gniadecki, R., Lukowsky, A., Rossen, K., Madsen, H. O., Thomsen, K., Wulf, H. C. (2003). Bone marrow precursor of extranodal T-cell lymphoma. Blood 102: 3797-3799 [Abstract] [Full Text]  
• Baron, F., Dresse, M.-F., Beguin, Y. (2003). Transmission of Chronic Myeloid Leukemia through Peripheral-Blood Stem-Cell Transplantation. NEJM 349: 913-914 [Full Text]