Sudden Death Due to Cardiac Arrhythmias

doi:10.1056/NEJMra000650

Volume 345:1473-1482		November 15, 2001		Number 20

Sudden Death Due to Cardiac Arrhythmias

Heikki V. Huikuri, M.D., Agustin Castellanos, M.D., and Robert J. Myerburg, M.D.

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Despite a substantial reduction in age-adjusted rates of deathfrom cardiovascular causes during the past 40 to 50 years, cardiovasculardisease remains the single most common cause of natural deathin developed nations.¹^,² Sudden death from cardiac causes isestimated to account for approximately 50 percent of all deathsfrom cardiovascular causes.¹^,² The majority of such sudden deathsare caused by acute ventricular tachyarrhythmias, often triggeredby acute coronary events, which may occur in persons withoutknown cardiac disease or in association with structural heartdisease.¹^,²^,³

Data from clinical electrophysiological studies and randomizedtrials have led to progress in the . . . [Full Text of this Article]

Mechanisms of Sudden Death from Arrhythmia

Epidemiology of Sudden Death from Cardiac Causes

Measures of the Risk of Lethal Arrhythmias

Cardiovascular Function

Ambient Ventricular Arrhythmias

Electrocardiographic Measures of Risk

Electrophysiological Testing

Variability in Heart Rate and Baroreflex Sensitivity

Prevention of Sudden Death

Primary-Prevention Trials

Secondary-Prevention Trials

Future Directions

Source Information

From the Division of Cardiology, Department of Medicine, University of Oulu, Oulu, Finland (H.V.H.); and the Division of Cardiology, University of Miami School of Medicine, Miami, Fla. (A.C., R.J.M.).

Address reprint requests to Dr. Huikuri at the Division of Cardiology, University of Oulu, Kajaanintie 50, 90220, Oulu, Finland, or at heikki.huikuri@oulu.fi.

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