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Review Article
Medical Progress
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Volume 345:1473-1482 November 15, 2001 Number 20
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Sudden Death Due to Cardiac Arrhythmias
Heikki V. Huikuri, M.D., Agustin Castellanos, M.D., and Robert J. Myerburg, M.D.

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Despite a substantial reduction in age-adjusted rates of death from cardiovascular causes during the past 40 to 50 years, cardiovascular disease remains the single most common cause of natural death in developed nations.1,2 Sudden death from cardiac causes is estimated to account for approximately 50 percent of all deaths from cardiovascular causes.1,2 The majority of such sudden deaths are caused by acute ventricular tachyarrhythmias, often triggered by acute coronary events, which may occur in persons without known cardiac disease or in association with structural heart disease.1,2,3

Data from clinical electrophysiological studies and randomized trials have led to progress in the . . . [Full Text of this Article]

Mechanisms of Sudden Death from Arrhythmia

Epidemiology of Sudden Death from Cardiac Causes

Measures of the Risk of Lethal Arrhythmias

Cardiovascular Function

Ambient Ventricular Arrhythmias

Electrocardiographic Measures of Risk

Electrophysiological Testing

Variability in Heart Rate and Baroreflex Sensitivity

Prevention of Sudden Death

Primary-Prevention Trials

Secondary-Prevention Trials

Future Directions


Source Information

From the Division of Cardiology, Department of Medicine, University of Oulu, Oulu, Finland (H.V.H.); and the Division of Cardiology, University of Miami School of Medicine, Miami, Fla. (A.C., R.J.M.).

Address reprint requests to Dr. Huikuri at the Division of Cardiology, University of Oulu, Kajaanintie 50, 90220, Oulu, Finland, or at heikki.huikuri@oulu.fi.

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