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Previous Volume 345:1502-1503 November 15, 2001 Number 20 Next

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To the Editor: Arzoo et al. (July 19 issue)¹ report on a 23-year-old woman with Langerhans'-cell histiocytosis and severe pain due to osteolytic lesions, who had a good response to a 90-mg infusion of pamidronate. Although the literature on the use of pamidronate in patients with Langerhans'-cell histiocytosis is scarce, there have been previous observations.^2,3,4

Elomaa and coworkers reported that the use of pamidronate (1.6 g per day orally for six months) in two adults with multifocal eosinophilic granuloma resulted in pain relief, regression of lesions, and biochemical evidence of decreased bone resorption.² Recently, my colleagues and I reported our . . . [Full Text of this Article]

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