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Correspondence
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Volume 345:1573-1575 November 22, 2001 Number 21
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Comparison of Early Invasive and Conservative Strategies in Patients with Unstable Coronary Syndromes

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To the Editor: In the randomized Treat Angina with Aggrastat and Determine Cost of Therapy with an Invasive or Conservative Strategy–Thrombolysis in Myocardial Infarction 18 (TACTICS–TIMI 18) trial, Cannon et al. (June 21 issue)1 compared the effects of early invasive and conservative strategies in patients with acute coronary syndromes. Two potential biases were not discussed in their report.

First, the definitions of myocardial infarction are not provided in the report, in the article outlining the study protocol,2 or in the article cited as providing "standard TIMI definitions."3 One must consult the TIMI 11B trial,4 whose results were published in 1999, . . . [Full Text of this Article]

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