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Correspondence
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Volume 345:1645-1646 November 29, 2001 Number 22
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Pituitary Carcinoma as a Cause of Acromegaly

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To the Editor: Only nine cases of acromegaly caused by pituitary carcinoma have been reported.1 We describe a 47-year-old woman who presented in July 1996 with the features of acromegaly and an elevated mean serum growth hormone level of 58.4 mU per liter. Magnetic resonance imaging demonstrated an extensive homogeneous pituitary mass compressing the optic chiasm, with extension to the suprasellar region and the right middle cranial fossa. Debulking was attempted transcranially, and histologic examination confirmed a pituitary adenoma that stained for growth hormone. The serum insulin-like growth factor I (IGF-I) level remained elevated at 158 nmol per liter (age- . . . [Full Text of this Article]

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