Aldosterone was isolated from blood and urine, its adrenal originelucidated, and its steroid structure identified nearly 50 yearsago. Actions involving the reabsorption of sodium and the releaseof potassium by epithelial cells in the kidneys, intestine,and sweat and salivary glands led to its designation as a mineralocorticoid.The physiologic importance of aldosterone in preventing theloss of salt and water during periods of dietary sodium deprivationis now clear. Its contribution to the retention of sodium inpatients with congestive heart failure, cirrhosis, and the nephroticsyndrome has also been established.1,2,3 The perception of itspathophysiologic importance . . . [Full Text of this Article]
The Renin–Angiotensin–Aldosterone System
Aldosterone and the Pathophysiology of Congestive Heart Failure
Congestive Heart Failure: A Salt-Avid Syndrome
Conclusions
Source Information
From the Division of Cardiovascular Diseases, Department of Medicine, University of Tennessee Health Science Center, Rm. 353 Dobbs Research Institute, 951 Court Ave., Memphis, TN 38163, where reprint requests should be addressed to Dr. Weber.
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