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Previous Volume 345:1772-1774 December 13, 2001 Number 24 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Type 2 diabetes, the most common form of diabetes, affects about 135 million people worldwide. Insulin resistance and dysfunction of pancreatic beta cells are central abnormalities of the disease. Insulin resistance is a disordered state in which insulin inadequately stimulates glucose transport in skeletal muscle and fat and inadequately suppresses hepatic glucose production. Glucose intolerance and then diabetes develop as the compensatory hypersecretion of insulin by beta cells declines. Knowledge of the molecular control of insulin secretion is therefore important for understanding the beta-cell dysfunction of type 2 diabetes. Zhang et al. recently provided compelling evidence that a mitochondrial anion . . . [Full Text of this Article]

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