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Age-related loss of memory and other cognitive abilities has been recognized since antiquity. However, the need to understand the causes and consequences of dementia has become urgent over the past quarter-century because of the large and increasing proportion of persons in the world's population who live into their 9th and 10th decades the ages at which people are at greatest risk for dementia. Dementia is now one of the most common and feared conditions of old age and is a major public health problem throughout the world. The condition demands more than a basic understanding on the part of
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