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Previous Volume 345:1842-1844 December 20, 2001 Number 25 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Despite the very large number of volunteers willing to donate bone marrow for unrelated recipients (currently numbering over 7 million worldwide), many candidate recipients still cannot obtain marrow because no HLA-matched volunteer can be found. The major histocompatibility complex (MHC), a group of closely linked genes on chromosome 6, encodes the class I and class II HLA molecules, which, in concert with T-cell receptors, make possible the immune recognition of foreign antigens. HLA molecules are also alloantigens that can trigger immune recognition and graft rejection in unmatched recipients.¹

HLA antigens in allografts, in allogeneic leukocytes in transfusions, and in fetal . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Ottinger, H. D., Ferencik, S., Beelen, D. W., Lindemann, M., Peceny, R., Elmaagacli, A. H., Husing, J., Grosse-Wilde, H. (2003). Hematopoietic stem cell transplantation: contrasting the outcome of transplantations from HLA-identical siblings, partially HLA-mismatched related donors, and HLA-matched unrelated donors. Blood 102: 1131-1137 [Abstract] [Full Text]