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Markers of the activation of coagulation may be of value. Besides prothrombin fragment F1+2, the thrombinantithrombin complex, plasminogen-activator inhibitor type 1, and tissue-plasminogen-activator antigen, d-dimer may be a good candidate. It is a specific clot-lysis product with a high negative predictive value for ruling out acute thromboembolic venous disease.2 The predictive
References
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