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Previous Volume 345:1855-1856 December 20, 2001 Number 25 Next

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To the Editor: In his review of subclinical hypothyroidism, Cooper (July 26 issue)¹ did not fully address the complex issue of prenatal screening. Since Haddow et al.² reported that the offspring of women with elevated thyrotropin concentrations had slightly but significantly lower IQ scores (by 4 points), there has been considerable controversy over the potential impact of thyroid screening during pregnancy on subsequent developmental delays in the children of these women.³

The efficacy at prenatal screening is unproved. Fetal neurologic development is most dependent on maternal thyroid hormone early in pregnancy, since fetal thyroxine is not detectable until 10 weeks' . . . [Full Text of this Article]

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