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Previous Volume 345:1856 December 20, 2001 Number 25 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Recent studies^1,2,3 have suggested that cyclooxygenase-2 (COX-2) inhibitors can be safely used in patients with asthma who have documented intolerance to COX-1 inhibitors such as aspirin and nonsteroidal antiinflammatory drugs. On the basis of these observations, we chose to treat a subject who had had an adverse reaction to a nonsteroidal antiinflammatory drug with the COX-2 inhibitor rofecoxib (Vioxx) in a supervised hospital setting.

A 63-year-old man with no history of asthma or allergic disease began treatment with diclofenac–misoprostol (Arthotec) in June 2001 for osteoarthritis. After one week of use, facial flushing and itching of the hands . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Page, N. A, Schroeder, W. S (2007). Rapid Desensitization Protocols for Patients with Cardiovascular Disease and Aspirin Hypersensitivity in an Era of Dual Antiplatelet Therapy. The Annals of Pharmacotherapy 41: 61-67 [Abstract] [Full Text]  
• Marshall, L. L (2005). Angioedema Associated with Aspirin and Rofecoxib. The Annals of Pharmacotherapy 39: 944-948 [Abstract] [Full Text]