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Previous Volume 345:1914-1915 December 27, 2001 Number 26 Next

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To the Editor: The issue of whether there is sympathetic reinnervation in the transplanted human heart remains debatable. Bengel et al. (Sept. 6 issue)¹ reported adrenergic activity in transplanted human hearts on the basis of the detection of the uptake of a catecholamine analogue by myocardium on positron-emission tomography. They claimed that sympathetic reinnervation occurred five years after heart transplantation and that the cardiac contractile response to exercise in patients with reinnervation was similar to that in normal controls. We question whether this cardiac adrenergic activity was indeed derived from the sympathetic reinnervation. If so, sympathetic nerve fibers would easily . . . [Full Text of this Article]

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