FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 345:175-179 July 19, 2001 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Aquaporin-1, the archetypal water-channel protein,¹ was initially identified in red cells and renal proximal tubular epithelium.² The gene for aquaporin-1 (AQP1) on chromosome 7 colocalizes with the Colton blood-group antigen,^3,4 and the Colton blood-group antigen polymorphism was identified as a substitution of a single amino acid in an extracellular domain of aquaporin-1.⁵ The International Blood Group Reference Laboratory has confirmed the existence of only six kindreds who lack the Colton blood group. Members of three of these kindreds were found to be homozygous for different mutations in the AQP1 gene, and their red-cell membranes had a complete absence . . . [Full Text of this Article]

Case Reports

Subject 1

Subject 2

Methods

Results

Discussion

Source Information

From the Divisions of Pulmonary and Critical Care Medicine (L.S.K.) and Nephrology (M.C.) and the Departments of Medicine (P.A.) and Biological Chemistry (L.S.K., P.A.), Johns Hopkins School of Medicine, Baltimore; the Penn Center for Molecular Kidney Diseases, University of Pennsylvania School of Medicine, Philadelphia (P.C.F.); and INSERM Unité 76, Paris (J.-P.C.).

Address reprint requests to Dr. King at the Division of Pulmonary and Critical Care Medicine, 600 N. Wolfe St., Blalock 910, Baltimore, MD 21287, or at lsking@welch.jhu.edu.

References

This article has been cited by other articles:

• Hague, W. M (2009). Diabetes insipidus in pregnancy. Obstet Med 2: 138-141 [Abstract] [Full Text]  
• Verkman, A. S. (2009). Aquaporins: translating bench research to human disease. J. Exp. Biol. 212: 1707-1715 [Abstract] [Full Text]  
• Fenton, R. A., Knepper, M. A. (2007). Mouse Models and the Urinary Concentrating Mechanism in the New Millennium. Physiol. Rev. 87: 1083-1112 [Abstract] [Full Text]  
• Lang, F., Vallon, V., Knipper, M., Wangemann, P. (2007). Functional significance of channels and transporters expressed in the inner ear and kidney. Am. J. Physiol. Cell Physiol. 293: C1187-C1208 [Abstract] [Full Text]  
• Floyd, R. V., Mason, S. L., Proudman, C. J., German, A. J., Marples, D., Mobasheri, A. (2007). Expression and nephron segment-specific distribution of major renal aquaporins (AQP1-4) in Equus caballus, the domestic horse. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293: R492-R503 [Abstract] [Full Text]  
• Marcovecchio, M L (2006). An infant with chronic hypernatremia. Eur J Endocrinol 155: S141-S144 [Abstract] [Full Text]  
• Belge, H., Devuyst, O. (2006). Aquaporin-1--a water channel on the move. Nephrol Dial Transplant 21: 2069-2071 [Full Text]  
• Schrier, R. W. (2006). Body Water Homeostasis: Clinical Disorders of Urinary Dilution and Concentration. J. Am. Soc. Nephrol. 17: 1820-1832 [Full Text]  
• Rai, T., Sasaki, S., Uchida, S. (2006). Polarized trafficking of the aquaporin-3 water channel is mediated by an NH2-terminal sorting signal. Am. J. Physiol. Cell Physiol. 290: C298-C304 [Abstract] [Full Text]  
• Chen, Y.-C., Cadnapaphornchai, M. A., Summer, S. N., Falk, S., Li, C., Wang, W., Schrier, R. W. (2005). Molecular Mechanisms of Impaired Urinary Concentrating Ability in Glucocorticoid-Deficient Rats. J. Am. Soc. Nephrol. 16: 2864-2871 [Abstract] [Full Text]  
• Chen, Y.-C., Cadnapaphornchai, M. A., Yang, J., Summer, S. N., Falk, S., Li, C., Wang, W., Schrier, R. W. (2005). Nonosmotic release of vasopressin and renal aquaporins in impaired urinary dilution in hypothyroidism. Am. J. Physiol. Renal Physiol. 289: F672-F678 [Abstract] [Full Text]  
• Verkman, A. S. (2005). More than just water channels: unexpected cellular roles of aquaporins. J. Cell Sci. 118: 3225-3232 [Abstract] [Full Text]  
• Umenishi, F., Yoshihara, S., Narikiyo, T., Schrier, R. W. (2005). Modulation of Hypertonicity-Induced Aquaporin-1 by Sodium Chloride, Urea, Betaine, and Heat Shock in Murine Renal Medullary Cells. J. Am. Soc. Nephrol. 16: 600-607 [Abstract] [Full Text]  
• (2004). Announcement. Am. J. Physiol. Renal Physiol. 287: F1296-F1296 [Full Text]  
• Sasaki, S. (2004). Nephrogenic diabetes insipidus: update of genetic and clinical aspects. Nephrol Dial Transplant 19: 1351-1353 [Full Text]  
• Knepper, M. A., Nielsen, S. (2004). Peter Agre, 2003 Nobel Prize Winner in Chemistry. J. Am. Soc. Nephrol. 15: 1093-1095 [Abstract] [Full Text]  
• Cadnapaphornchai, M. A., Summer, S. N., Falk, S., Thurman, J. M., Knepper, M. A., Schrier, R. W. (2003). Effect of primary polydipsia on aquaporin and sodium transporter abundance. Am. J. Physiol. Renal Physiol. 285: F965-F971 [Abstract] [Full Text]  
• Tietz, P. S., Marinelli, R. A., Chen, X.-M., Huang, B., Cohn, J., Kole, J., McNiven, M. A., Alper, S., LaRusso, N. F. (2003). Agonist-induced Coordinated Trafficking of Functionally Related Transport Proteins for Water and Ions in Cholangiocytes. J. Biol. Chem. 278: 20413-20419 [Abstract] [Full Text]  
• Umenishi, F., Schrier, R. W. (2003). Hypertonicity-induced Aquaporin-1 (AQP1) Expression Is Mediated by the Activation of MAPK Pathways and Hypertonicity-responsive Element in the AQP1 Gene. J. Biol. Chem. 278: 15765-15770 [Abstract] [Full Text]  
• Cadnapaphornchai, M. A., Kim, Y.-W., Gurevich, A. K., Summer, S. N., Falk, S., Thurman, J. M., Schrier, R. W. (2003). Urinary Concentrating Defect in Hypothyroid Rats: Role of Sodium, Potassium, 2-Chloride Co-Transporter, and Aquaporins. J. Am. Soc. Nephrol. 14: 566-574 [Abstract] [Full Text]  
• Wagner, F. F., Poole, J., Flegel, W. A. (2003). Scianna antigens including Rd are expressed by ERMAP. Blood 101: 752-757 [Abstract] [Full Text]  
• Roudier, N., Ripoche, P., Gane, P., Le Pennec, P. Y., Daniels, G., Cartron, J.-P., Bailly, P. (2002). AQP3 Deficiency in Humans and the Molecular Basis of a Novel Blood Group System, GIL. J. Biol. Chem. 277: 45854-45859 [Abstract] [Full Text]  
• Goodman, B. E. (2002). TRANSPORT OF SMALL MOLECULES ACROSS CELL MEMBRANES: WATER CHANNELS AND UREA TRANSPORTERS. Adv. Physiol. Educ. 26: 146-157 [Abstract] [Full Text]  
• Agre, P., King, L. S, Yasui, M., Guggino, W. B, Ottersen, O. P., Fujiyoshi, Y., Engel, A., Nielsen, S. (2002). Aquaporin water channels - from atomic structure to clinical medicine. J. Physiol. 542: 3-16 [Abstract] [Full Text]  
• Nielsen, S., Frokiar, J., Marples, D., Kwon, T.-H., Agre, P., Knepper, M. A. (2002). Aquaporins in the Kidney: From Molecules to Medicine. Physiol. Rev. 82: 205-244 [Abstract] [Full Text]  
• Nejsum, L. N., Kwon, T.-H., Jensen, U. B., Fumagalli, O., Frokiaer, J., Krane, C. M., Menon, A. G., King, L. S., Agre, P. C., Nielsen, S. (2002). Functional requirement of aquaporin-5 in plasma membranes of sweat glands. Proc. Natl. Acad. Sci. USA 10.1073/pnas.012588099v1 [Abstract] [Full Text]  
• King, L. S., Nielsen, S., Agre, P., Brown, R. H. (2002). Decreased pulmonary vascular permeability in aquaporin-1-null humans. Proc. Natl. Acad. Sci. USA 10.1073/pnas.022626499v1 [Abstract] [Full Text]  
• Saparov, S. M., Kozono, D., Rothe, U., Agre, P., Pohl, P. (2001). Water and Ion Permeation of Aquaporin-1 in Planar Lipid Bilayers. MAJOR DIFFERENCES IN STRUCTURAL DETERMINANTS AND STOICHIOMETRY. J. Biol. Chem. 276: 31515-31520 [Abstract] [Full Text]  
• Nejsum, L. N., Kwon, T.-H., Jensen, U. B., Fumagalli, O., Frokiaer, J., Krane, C. M., Menon, A. G., King, L. S., Agre, P. C., Nielsen, S. (2002). Functional requirement of aquaporin-5 in plasma membranes of sweat glands. Proc. Natl. Acad. Sci. USA 99: 511-516 [Abstract] [Full Text]  
• King, L. S., Nielsen, S., Agre, P., Brown, R. H. (2002). Decreased pulmonary vascular permeability in aquaporin-1-null humans. Proc. Natl. Acad. Sci. USA 99: 1059-1063 [Abstract] [Full Text]