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Previous Volume 345:224-225 July 19, 2001 Number 3 Next

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To the Editor: We summarize cases of myocarditis and cardiomyopathy reported to the Food and Drug Administration (FDA) in patients treated with the atypical antipsychotic medication clozapine. Because it carries risks of agranulocytosis and seizures, clozapine is indicated for patients with severe schizophrenia who have no response to or who cannot tolerate standard antipsychotic agents. Between the U.S. approval of clozapine in September 1989 and December 2, 1999, the FDA received reports of 28 cases of myocarditis, including 18 deaths, and 41 cases of cardiomyopathy, including 10 deaths, that were temporally associated with the use of clozapine and that met . . . [Full Text of this Article]

References

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