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Original Article
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Volume 345:256-258 July 26, 2001 Number 4
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Glanders in a Military Research Microbiologist
Arjun Srinivasan, M.D., Carl N. Kraus, M.D., David DeShazer, Ph.D., Patrice M. Becker, M.D., James D. Dick, Ph.D., Lisa Spacek, M.D., John G. Bartlett, M.D., W. Russell Byrne, M.D., and David L. Thomas, M.D.

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 by Khan, A. S.

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Infection with Burkholderia mallei (formerly Pseudomonas mallei) can cause a subcutaneous infection known as farcy or can disseminate to cause the condition known as glanders. In humans, acute infection with B. mallei is characterized by necrosis of the tracheobronchial tree, pustular skin lesions, and either a febrile pneumonia, if the organism was inhaled, or signs of sepsis and multiple abscesses, if the skin was the portal of entry.1 At the turn of the 20th century, glanders was an important cause of death among horses, and there were secondary, often fatal, infections in humans.2 Because of the lethal and contagious . . . [Full Text of this Article]

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From the Division of Infectious Diseases (A.S., L.S., J.G.B., D.L.T.), the Division of Pulmonary and Critical Care Medicine (P.M.B.), and the Department of Pathology (J.D.D.), Johns Hopkins Medical Institutions, Baltimore; the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. (C.N.K.); and the U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Md. (D.D., W.R.B.).

Address reprint requests to Dr. Thomas at 424 N. Bond St., Baltimore, MD 21231.

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