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Correspondence
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Volume 345:292-293 July 26, 2001 Number 4
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Low-Molecular-Weight Heparin in Patients with Deep-Vein Thrombosis

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To the Editor: The clinical importance of rapidly achieving a therapeutic activated partial-thromboplastin time with respect to the treatment of venous thromboembolism with unfractionated heparin has been underscored in various studies1 and reviews.2 Breddin et al. (March 1 issue)3 compared intravenous unfractionated heparin with subcutaneous weight-adjusted reviparin, given once or twice a day, as a therapy for deep-vein thrombosis. Reviparin (a low-molecular-weight heparin) was more effective than unfractionated heparin in reducing the size of the thrombus, and twice-daily administration of reviparin prevented recurrent thromboembolism better than did treatment with unfractionated heparin. The patients received fixed initial doses of unfractionated heparin, . . . [Full Text of this Article]

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