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Previous Volume 345:293-294 July 26, 2001 Number 4 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Cardiac output is determined by heart rate and stroke volume. Since the latter is reduced in patients with ventricular systolic dysfunction, the cardiovascular reserve during exercise in patients with heart failure depends heavily on the increment of the pulse rate. Unfortunately, chronotropic insufficiency is often found in these patients. Moreover, substantial prognostic value has been attributed to this abnormality.¹ We were therefore surprised that Cazeau et al. (March 2 issue),² in their report of the Multisite Stimulation in Cardiomyopathies trial, did not provide information on the maximal heart rates achieved during exercise before and after three months . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Turner, M. S., Bleasdale, R. A., Vinereanu, D., Mumford, C. E., Paul, V., Fraser, A. G., Frenneaux, M. P. (2004). Electrical and Mechanical Components of Dyssynchrony in Heart Failure Patients With Normal QRS Duration and Left Bundle-Branch Block: Impact of Left and Biventricular Pacing. Circulation 109: 2544-2549 [Abstract] [Full Text]