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Correspondence
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Volume 345:296-297 July 26, 2001 Number 4
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Cutaneous Squamous-Cell Carcinoma

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To the Editor: In their excellent review article on cutaneous squamous-cell cancers (March 29 issue),1 Alam and Ratner mention sunscreen use but not the prevention of these cancers in certain populations of patients at high risk. Among recipients of solid-organ transplants, the incidence of cutaneous squamous-cell carcinoma may be more than 100 times the incidence in the general population.2 Moreover, as many as 6 percent of renal-allograft recipients with skin cancer may die of metastases.

Prophylactic measures, including the daily use of topical tretinoin, enhance the number and function of dendritic cells within the skin, a change seen in association . . . [Full Text of this Article]

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