Idiopathic Pulmonary Fibrosis

doi:10.1056/NEJMra003200

Volume 345:517-525		August 16, 2001		Number 7

Idiopathic Pulmonary Fibrosis

Thomas J. Gross, M.D., and Gary W. Hunninghake, M.D.

Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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PubMed Citation

Idiopathic pulmonary fibrosis is characterized by radiographicallyevident interstitial infiltrates predominantly affecting thelung bases and by progressive dyspnea and worsening of pulmonaryfunction. No therapy has been clearly shown to prolong survival.¹The current strict definition of idiopathic pulmonary fibrosisprovides a new focus for basic and clinical research that willimprove insight into the pathogenesis of this disorder and stimulatethe development of novel therapies.

Definition

Idiopathic pulmonary fibrosis, also known as cryptogenic fibrosingalveolitis, is one of a family of idiopathic pneumonias sharingthe clinical features of shortness of breath, radiographicallyevident diffuse pulmonary infiltrates, and varying degrees . . . [Full Text of this Article]

Pathogenesis

Diagnosis

Natural History

Therapy

Antiinflammatory Agents

Antifibrotic Agents

Immune Modulators

Lung Transplantation

Summary

Source Information

From the Division of Pulmonary, Critical Care, and Occupational Medicine, Department of Internal Medicine, University of Iowa College of Medicine and Veterans Affairs Medical Center, Iowa City.

Address reprint requests to Dr. Hunninghake at the Division of Pulmonary, Critical Care, and Occupational Medicine, Department of Internal Medicine, Room C33-GH, University of Iowa Health Care, Iowa City, IA 52242, or at gary-hunninghake@uiowa.edu.

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