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Previous Volume 345:548 August 16, 2001 Number 7 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Whipple's disease is an infection that affects primarily the intestine, but some cases involve the heart valve, the peripheral lymph nodes, the joints, and the central nervous system.¹ Recently, the establishment of Tropheryma whipplei (formerly T. whippelii, the causative agent of Whipple's disease)² in culture allowed the generation of antibodies against the bacterium³ that we used for immunostaining the valve² or duodenal specimen³ of infected patients. Here, we report the immunodetection of T. whipplei in the circulating monocytes of a patient with untreated Whipple's disease.

A 70-year-old man was hospitalized in December 2000 for fatigue, weight loss, . . . [Full Text of this Article]

References

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• Ventura, M., Canchaya, C., Tauch, A., Chandra, G., Fitzgerald, G. F., Chater, K. F., van Sinderen, D. (2007). Genomics of Actinobacteria: Tracing the Evolutionary History of an Ancient Phylum. Microbiol. Mol. Biol. Rev. 71: 495-548 [Abstract] [Full Text]  
• Desnues, B., Ihrig, M., Raoult, D., Mege, J.-L. (2006). Whipple's Disease: a Macrophage Disease. CVI 13: 170-178 [Full Text]  
• Drevets, D. A., Leenen, P. J. M., Greenfield, R. A. (2004). Invasion of the Central Nervous System by Intracellular Bacteria. Clin. Microbiol. Rev. 17: 323-347 [Abstract] [Full Text]  
• Drancourt, M., Raoult, D., Lepidi, H., Fenollar, F., Birg, M.-L., Bodaghi, B., Hoang, P. L., Lelievre, J.-D. (2003). Culture of Tropheryma whippelii from the Vitreous Fluid of a Patient Presenting with Unilateral Uveitis. ANN INTERN MED 139: 1046-1047 [Full Text]  
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• Lange, U., Teichmann, J. (2003). Whipple arthritis: diagnosis by molecular analysis of synovial fluid--current status of diagnosis and therapy. Rheumatology (Oxford) 42: 473-480 [Abstract] [Full Text]