FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Volume 346:2-4 January 3, 2002 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Quaini, F. PubMed Citation

Bone marrow, the liver, and intestinal epithelium can regenerate, but the conventional teaching is that the heart cannot, because cardiac myocytes cannot divide. Consequently, it is generally accepted that the basis of cardiac enlargement and remodeling in response to disease or excessive work is an increase in the size of individual heart cells (hypertrophy) but not in their number (hyperplasia).

Hypertrophy is a beneficial response to the demand for increased cardiac work, but it has drawbacks. Since myocytes cannot enlarge indefinitely, the extent to which the heart can adapt through hypertrophy has intrinsic limits. A sustained hemodynamic overload may end . . . [Full Text of this Article]

Cell Division in the Heart

The Role of Stem Cells

This article has been cited by other articles:

• Bearzi, C., Leri, A., Lo Monaco, F., Rota, M., Gonzalez, A., Hosoda, T., Pepe, M., Qanud, K., Ojaimi, C., Bardelli, S., D'Amario, D., D'Alessandro, D. A., Michler, R. E., Dimmeler, S., Zeiher, A. M., Urbanek, K., Hintze, T. H., Kajstura, J., Anversa, P. (2009). Identification of a coronary vascular progenitor cell in the human heart. Proc. Natl. Acad. Sci. USA 106: 15885-15890 [Abstract] [Full Text]  
• Anversa, P., Leri, A., Kajstura, J. (2006). Cardiac Regeneration. J Am Coll Cardiol 47: 1769-1776 [Abstract] [Full Text]  
• Leri, A., Kajstura, J., Anversa, P. (2005). Cardiac Stem Cells and Mechanisms of Myocardial Regeneration. Physiol. Rev. 85: 1373-1416 [Abstract] [Full Text]  
• Urbanek, K., Quaini, F., Tasca, G., Torella, D., Castaldo, C., Nadal-Ginard, B., Leri, A., Kajstura, J., Quaini, E., Anversa, P. (2003). From The Cover: Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy. Proc. Natl. Acad. Sci. USA 100: 10440-10445 [Abstract] [Full Text]  
• Bayes-Genis, A., Salido, M., Sole Ristol, F., Puig, M., Brossa, V., Camprecios, M., Corominas, J. M, Marinoso, M{a} L., Baro, T., Vela, M{a} C., Serrano, S., Padro, J. M, Bayes de Luna, A., Cinca, J. (2002). Host cell-derived cardiomyocytes in sex-mismatch cardiac allografts. Cardiovasc Res 56: 404-410 [Abstract] [Full Text]  
• (2002). Definitive Proof: New Cells Can Develop in the Heart. JWatch General 2002: 1-1 [Full Text]