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Editorial
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Volume 346:58-61 January 3, 2002 Number 1
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The Hemolytic–Uremic Syndrome — Toxin, Thrombin, and Thrombosis

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 by Chandler, W. L.
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The term "hemolytic–uremic syndrome" was coined by Gasser et al. in 19551 to describe a devastating illness consisting of acute renal failure accompanied by nonimmune hemolytic anemia and thrombocytopenia. Although it may be seen in adolescents and adults, the hemolytic–uremic syndrome most frequently occurs in young children (under the age of five years) after a prodromal period of bloody diarrhea caused by Shiga toxin from Escherichia coli (especially serotype O157:H7). Multiorgan failure involving the central nervous system, pancreas, heart, or other systems or organs may accompany this disease. The differential diagnosis includes, not surprisingly, disseminated intravascular coagulation, primary hemolytic anemia, . . . [Full Text of this Article]

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