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Previous Volume 346:63-65 January 3, 2002 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In the July 5 issue of the Journal, Manson and Martin review the clinical controversies surrounding hormone-replacement therapy.¹ The findings of the Heart and Estrogen/Progestin Replacement Study (HERS) suggest reasons to be cautious about the use of hormone-replacement therapy in women who are 65 years of age or older. Of 2763 women (mean age, 67 years) with established coronary heart disease, women who were randomly assigned to receive hormone-replacement therapy had an excess risk of one additional blood clot per 64 women and of one additional gallbladder operation per 69 women during a four-year period.^2,3 Hormone-replacement therapy . . . [Full Text of this Article]

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