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Previous Volume 346:1025-1026 March 28, 2002 Number 13 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Rivers et al. (Nov. 8 issue)¹ report on goal-directed therapy for severe sepsis and septic shock. Although their findings are interesting and provocative, they should be interpreted with caution. The end points of therapy and the treatment approaches used are somewhat troubling. The central venous pressure is a poor indicator of intravascular volume.² Furthermore, mixed venous oxygen saturation (SmvO₂), and, by inference, central venous oxygen saturation (ScvO₂), are poorly correlated with cardiac output and indexes of tissue oxygenation.^2,3 The use of packed cells as first-line therapy to increase the ScvO₂ in the patients assigned to . . . [Full Text of this Article]

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