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Previous Volume 346:995-1008 March 28, 2002 Number 13 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Immune thrombocytopenic purpura is an autoimmune disorder characterized by a low platelet count and mucocutaneous bleeding. The estimated incidence is 100 cases per 1 million persons per year, and about half of these cases occur in children.^1,2,3 Immune thrombocytopenic purpura is classified as primary or as secondary to an underlying disorder and as acute (of six months or less in duration) or chronic. Adult-onset and childhood-onset immune thrombocytopenic purpura are strikingly different. Affected children are young (peak age, approximately five years) and previously healthy, and they typically present with the sudden onset of petechiae or purpura a few days or . . . [Full Text of this Article]

Pathophysiology

Genetics

Diagnosis

Measuring Platelet-Associated Antibodies

Initial Management

Adults

Children

Urgent Treatment

Management of First Relapse

Adults

Children

Splenectomy

Adults

Children

Sepsis after Splenectomy

Chronic Refractory Immune Thrombocytopenic Purpura

Adults

Children

Immune Thrombocytopenic Purpura during Pregnancy

Mortality

The Patient's Perspective

The Physician's Perspective

Source Information

From the Departments of Pathology and Laboratory Medicine and of Medicine, University of Pennsylvania, Philadelphia (D.B.C.); and the Division of Haematology and Oncology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto (V.S.B.).

Address reprint requests to Dr. Cines at the Department of Pathology and Laboratory Medicine, University of Pennsylvania, 513 A Stellar-Chance, 422 Curie Blvd., Philadelphia, PA 19104, or at dcines@mail.med.upenn.edu.

References

Related Letters:

Immune Thrombocytopenic Purpura
Khouri I., Tuan B., Grant K., Bleesing J. J.H., Fleisher T. A., McCarthy L. J., Dzik W., Cines D. B., Blanchette V. S.
Extract | Full Text | PDF  
N Engl J Med 2002; 347:449-450, Aug 8, 2002. Correspondence

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