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Previous Volume 346:1085-1087 April 4, 2002 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In their prevention trial, published in this issue of the Journal, Giardiello et al. showed that the nonsteroidal antiinflammatory drug (NSAID) sulindac did not inhibit the development of colorectal adenomatous polyps in subjects with genotypically proven familial adenomatous polyposis who had an endoscopically normal colon at the commencement of treatment.¹ Why did this approach fail, and what are the lessons for the prevention and treatment of sporadic colorectal cancer and other cancers?

The prevalence of familial adenomatous polyposis is about 1 in 8000. It is an autosomal dominant condition in which at least 100 and up to thousands of adenomatous . . . [Full Text of this Article]

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