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Previous Volume 346:1092-1093 April 4, 2002 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Brown et al. (Nov. 29 issue)¹ report the nonsignificant effect of antioxidants on angiographic and clinical outcomes in patients with coronary disease and low levels of high-density lipoprotein (HDL) cholesterol. However, the study appears to be underpowered to demonstrate reliably that antioxidant therapy has no meaningful benefit in this population. Moreover, the authors neither provided power analysis in the Methods section nor acknowledged this limitation in the Discussion section.

In the Results section, the researchers affirm that among the 34 patients in the placebo group, the mean percentage of stenosis in proximal arteries increased by a mean . . . [Full Text of this Article]

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