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Correspondence
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Volume 346:1173-1174 April 11, 2002 Number 15
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Valsartan in Chronic Heart Failure

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To the Editor: Cohn and Tognoni (Dec. 6 issue)1 found that the angiotensin-receptor blocker valsartan reduced the combined end point of mortality and morbidity and improved clinical signs and symptoms in patients with heart failure when it was added to prescribed therapy. However, an adverse effect on mortality and morbidity was observed in a subgroup receiving valsartan, an angiotensin-converting–enzyme (ACE) inhibitor, and a beta-blocker. In the overall study, adverse events leading to the discontinuation of valsartan included dizziness, hypotension, and renal impairment, but hypotension was not significantly more frequent in the valsartan group than in the placebo group. The authors . . . [Full Text of this Article]

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