FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 346:1212-1220 April 18, 2002 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

In 1851, Theodor Bilharz described a parasitic infection (bilharzia) that would later be termed schistosomiasis. Currently, 200 million people in 74 countries have this disease; 120 million of them have symptoms, and 20 million have severe illness.¹ Schistosomiasis is caused by parasitic trematode worms (schistosomes) that reside in the abdominal veins of their vertebrate definitive hosts. The life cycle of the schistosome is depicted in Figure 1. Schistosomiasis is 1 of the 10 tropical diseases especially targeted for control by the Special Program for Research and Training in Tropical Diseases of the United Nations Development Program, the World Bank, . . . [Full Text of this Article]

Pathophysiology and Clinical Disease

Immediate Manifestations

Acute Schistosomiasis

Chronic Schistosomiasis

            Gastrointestinal and Liver Disease

            Genitourinary Disease

            Neurologic and Other Manifestations

Infections in Travelers and Immigrants

Susceptibility

Diagnosis

Treatment and Chemoprophylaxis

Vaccine Development

Source Information

From the Medical University of the Americas, Charlestown, Nevis, West Indies (A.G.P.R.); the Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, and the University of Queensland, Brisbane, Australia (P.B.B., A.C.S., Y.L., G.M.W., D.P.M.); and the Department of Medicine, Medical College of Wisconsin, Milwaukee (G.R.O.).

Address reprint requests to Dr. McManus at the Queensland Institute of Medical Research, 300 Herston Rd., Brisbane, Queensland 4029, Australia, or at donm@qimr.edu.au.

References

Related Letters:

Schistosomiasis
Schwartz E., Rozenman J., Bhigjee A., Halkic N., Gintzburger D., Bartley P. B., McManus D. P.
Extract | Full Text | PDF  
N Engl J Med 2002; 347:766-768, Sep 5, 2002. Correspondence

This article has been cited by other articles:

• Landeyro, J., Elguezabal, A., Gene, M., Garcia-Fontgivell, J., Mayayo, E. (2009). Rectal Inflammatory Polyp in a Child: An Unusual Case of Polyparasitism. J Trop Pediatr 0: fmp117v1-fmp117 [Abstract] [Full Text]  
• Catalano, O. A., Sahani, D. V., Forcione, D. G., Czermak, B., Liu, C.-H., Soricelli, A., Arellano, R. S., Muller, P. R., Hahn, P. F. (2009). Biliary Infections: Spectrum of Imaging Findings and Management. RadioGraphics 29: 2059-2080 [Abstract] [Full Text]  
• de Gorgolas, M., Casado, V., Renedo, G., Alen, J. F., Guerrero, M. L. F. (2009). Nodular Lung Schistosomiais Lesions after Chemotherapy for Dysgerminoma. Am J Trop Med Hyg 81: 424-427 [Abstract] [Full Text]  
• PASSOS, M C F, SILVA, L C, FERRARI, T C A, FARIA, L C (2009). Ultrasound and CT findings in hepatic and pancreatic parenchyma in acute schistosomiasis. Br. J. Radiol. 82: e145-e147 [Abstract] [Full Text]  
• Lapa, M., Dias, B., Jardim, C., Fernandes, C. J.C., Dourado, P. M.M., Figueiredo, M., Farias, A., Tsutsui, J., Terra-Filho, M., Humbert, M., Souza, R. (2009). Cardiopulmonary Manifestations of Hepatosplenic Schistosomiasis. Circulation 119: 1518-1523 [Abstract] [Full Text]  
• Souza, R., Jardim, C. (2009). Trends in pulmonary arterial hypertension. ERR 18: 7-12 [Full Text]  
• Brodine, S. K., Thomas, A., Huang, R., Harbertson, J., Mehta, S., Leake, J., Nutman, T., Moser, K., Wolf, J., Ramanathan, R., Burbelo, P., Nou, J., Wilkins, P., Reed, S. L. (2009). Community Based Parasitic Screening and Treatment of Sudanese Refugees: Application and Assessment of Centers for Disease Control Guidelines. Am J Trop Med Hyg 80: 425-430 [Abstract] [Full Text]  
• Argemi, X., Camuset, G., Abou-Bakar, A., Lucescu, I., Forestier, E., Christmann, D., Hansmann, Y. (2009). Rectal Perforation Caused by Schistosoma haematobium. Am J Trop Med Hyg 80: 179-181 [Abstract] [Full Text]  
• Million, M, Doudier, B, Soussan, J, Subtil, C, Meunier-Carpentier, S, Parola, P (2008). Fever and eosinophilia in a returned traveller. Postgrad. Med. J. 84: 613-614 [Full Text]  
• Makinson, A., Morales, R. J., Basset, D., Bouchaud, O., Verdon, R., Hosseini, H., Moing, V. L., Delaporte, E., Reynes, J. (2008). DIAGNOSTIC APPROACHES TO IMPORTED SCHISTOSOMAL MYELORADICULOPATHY IN TRAVELERS. Neurology 71: 66-67 [Full Text]  
• Bezerra, A. S. d. A., D'Ippolito, G., Caldana, R. P., Leopoldino, D. D., Batista, G. R., Borges, D. R., de Jesus Lopes Filho, G., Ahmed, M. (2008). Differentiating Cirrhosis and Chronic Hepatosplenic Schistosomiasis Using MRI. Am. J. Roentgenol. 190: W201-W207 [Abstract] [Full Text]  
• Martin-Davila, P., Fortun, J., Lopez-Velez, R., Norman, F., Montes de Oca, M., Zamarron, P., Gonzalez, M. I., Moreno, A., Pumarola, T., Garrido, G., Candela, A., Moreno, S. (2008). Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation. Clin. Microbiol. Rev. 21: 60-96 [Abstract] [Full Text]  
• McManus, D. P., Loukas, A. (2008). Current Status of Vaccines for Schistosomiasis. Clin. Microbiol. Rev. 21: 225-242 [Abstract] [Full Text]  
• Corstjens, P. L. A. M., van Lieshout, L., Zuiderwijk, M., Kornelis, D., Tanke, H. J., Deelder, A. M., van Dam, G. J. (2008). Up-Converting Phosphor Technology-Based Lateral Flow Assay for Detection of Schistosoma Circulating Anodic Antigen in Serum. J. Clin. Microbiol. 46: 171-176 [Abstract] [Full Text]  
• Watanabe, K., Mwinzi, P. N. M., Black, C. L., Muok, E. M. O., Karanja, D. M. S., Secor, W. E., Colley, D. G. (2007). T Regulatory Cell Levels Decrease in People Infected With Schistosoma mansoni on Effective Treatment. Am J Trop Med Hyg 77: 676-682 [Abstract] [Full Text]  
• (2007). Image of the Month--Diagnosis. Arch Surg 142: 488-488 [Full Text]  
• Wethington, A. R., Zavodna, M., Smith, M. K., Oliveira, G., Lewis, F., Minchella, D. J. (2007). Population genetic structure of Biomphalaria glabrata in a schistosomiasis-endemic region in Brazil. J MOLLUS STUD 73: 45-52 [Abstract] [Full Text]  
• Yen, L., Magnier, M., Weissleder, R., Stockwell, B. R., Mulligan, R. C. (2006). Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries. RNA 12: 797-806 [Abstract] [Full Text]  
• Artal, F J C, Mesquita, H M, de A Gepp, R, Antunes, J S, Kalil, R K (2006). Brain involvement in a Schistosoma mansoni myelopathy patient. J. Neurol. Neurosurg. Psychiatry 77: 512-512 [Full Text]  
• Stone, C. (2005). Schistosomiasis. Journal of Diagnostic Medical Sonography 21: 424-427 [Abstract]  
• RILEY, S., CARABIN, H., MARSHALL, C., OLVEDA, R., WILLINGHAM, A. L., McGARVEY, S. T. (2005). ESTIMATING AND MODELING THE DYNAMICS OF THE INTENSITY OF INFECTION WITH SCHISTOSOMA JAPONICUM IN VILLAGERS OF LEYTE, PHILIPPINES. PART II: INTENSITY-SPECIFIC TRANSMISSION OF S. JAPONICUM. THE SCHISTOSOMIASIS TRANSMISSION AND ECOLOGY PROJECT. Am J Trop Med Hyg 72: 754-761 [Abstract] [Full Text]  
• Betting, L. E., Pirani, C. Jr, Queiroz, L. d. S., Damasceno, B. P., Cendes, F. (2005). Seizures and Cerebral Schistosomiasis. Arch Neurol 62: 1008-1010 [Abstract] [Full Text]  
• Kumari, S B, Allan, P S (2005). Trematodes in two travellers. JRSM 98: 25-26 [Full Text]  
• Hirschmann, J. V., Richardson, P., Kraemer, R. S., Mackowiak, P. A. (2004). Herod the Great and Polyarteritis Nodosa--Reply. Arch Intern Med 164: 2508-2509 [Full Text]  
• van Bolhuis, G. H., Rijks, J. M., Dorrestein, G. M., Rudolfova, J., van Dijk, M., Kuiken, T. (2004). Obliterative Endophlebitis in Mute Swans (Cygnus olor) Caused by Trichobilharzia sp. (Digenea: Schistosomatidae) Infection. Vet Pathol 41: 658-665 [Abstract] [Full Text]  
• Neal, P. M. (2004). Schistosomiasis - An Unusual Cause of Ureteral Obstruction: A Case History and Perspective. Clin Med Res 2: 216-227 [Abstract] [Full Text]  
• STIENSTRA, Y., VAN DER WERF, T. S., VAN DER GRAAF, W. T. A., SECOR, W. E., KIHLSTROM, S. L., DOBOS, K. M., ASAMOA, K., QUARSHI, E., ETUAFUL, S. N., KLUTSE, E. Y., KING, C. H. (2004). BURULI ULCER AND SCHISTOSOMIASIS: NO ASSOCIATION FOUND. Am J Trop Med Hyg 71: 318-321 [Abstract] [Full Text]  
• van den Berg, T. K., Honing, H., Franke, N., van Remoortere, A., Schiphorst, W. E. C. M., Liu, F.-T., Deelder, A. M., Cummings, R. D., Hokke, C. H., van Die, I. (2004). LacdiNAc-Glycans Constitute a Parasite Pattern for Galectin-3-Mediated Immune Recognition. J. Immunol. 173: 1902-1907 [Abstract] [Full Text]  
• Carod Artal, F. J., Vargas, A. P., Horan, T. A., Marinho, P. B., Coelho Costa, P. H. (2004). Schistosoma mansoni myelopathy: Clinical and pathologic findings. Neurology 63: 388-391 [Abstract] [Full Text]  
• ACOSTA, L. P., MCMANUS, D. P., ALIGUI, G. DL., OLVEDA, R. M., TIU, W. U. (2004). ANTIGEN-SPECIFIC ANTIBODY ISOTYPE PATTERNS TO SCHISTOSOMA JAPONICUM RECOMBINANT AND NATIVE ANTIGENS IN A DEFINED POPULATION IN LEYTE, THE PHILIPPINES. Am J Trop Med Hyg 70: 549-555 [Abstract] [Full Text]  
• Prodhan, P., Noviski, N., Mendiratta, P., Wright, D. A., Young, R. H., Heney, N. M. (2004). Case 39-2003: A Woman with Gross Hematuria. NEJM 350: 1687-1688 [Full Text]  
• Hesse, M., Piccirillo, C. A., Belkaid, Y., Prufer, J., Mentink-Kane, M., Leusink, M., Cheever, A. W., Shevach, E. M., Wynn, T. A. (2004). The Pathogenesis of Schistosomiasis Is Controlled by Cooperating IL-10-Producing Innate Effector and Regulatory T Cells. J. Immunol. 172: 3157-3166 [Abstract] [Full Text]  
• DURAND, F., BRION, J.-P., TERRIER, N., PINEL, C., PELLOUX, H. (2004). FUNICULITIS DUE TO SCHISTOSOMA HAEMATOBIUM: UNCOMMON DIAGNOSIS USING PARASITOLOGIC ANALYSIS OF SEMEN. Am J Trop Med Hyg 70: 46-47 [Abstract] [Full Text]  
• Huaux, F., Liu, T., McGarry, B., Ullenbruch, M., Xing, Z., Phan, S. H. (2003). Eosinophils and T Lymphocytes Possess Distinct Roles in Bleomycin-Induced Lung Injury and Fibrosis. J. Immunol. 171: 5470-5481 [Abstract] [Full Text]  
• Siddiqui, A. A., Phillips, T., Charest, H., Podesta, R. B., Quinlin, M. L., Pinkston, J. R., Lloyd, J. D., Paz, M., Villalovos, R. M., Pompa, J. (2003). Induction of Protective Immunity against Schistosoma mansoni via DNA Priming and Boosting with the Large Subunit of Calpain (Sm-p80): Adjuvant Effects of Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-4. Infect. Immun. 71: 3844-3851 [Abstract] [Full Text]  
• van Die, I., van Vliet, S. J., Nyame, A. K., Cummings, R. D., Bank, C. M.C., Appelmelk, B., Geijtenbeek, T. B.H., van Kooyk, Y. (2003). The dendritic cell-specific C-type lectin DC-SIGN is a receptor for Schistosoma mansoni egg antigens and recognizes the glycan antigen Lewis x. Glycobiology 13: 471-478 [Abstract] [Full Text]  
• Utzinger, J., Keiser, J., Shuhua, X., Tanner, M., Singer, B. H. (2003). Combination Chemotherapy of Schistosomiasis in Laboratory Studies and Clinical Trials. Antimicrob. Agents Chemother. 47: 1487-1495 [Full Text]  
• Schwartz, E., Rozenman, J., Bhigjee, A., Halkic, N., Gintzburger, D., Bartley, P. B., McManus, D. P. (2002). Schistosomiasis. NEJM 347: 766-768 [Full Text]  
• (2002). Vulvar Lesion in a 45-Year-Old Woman. Arch Dermatol 138: 1245-1250 [Full Text]