Nonalcoholic fatty liver disease is an increasingly recognizedcondition that may progress to end-stage liver disease. Thepathological picture resembles that of alcohol-induced liverinjury, but it occurs in patients who do not abuse alcohol.1,2A variety of terms have been used to describe this entity, includingfatty-liver hepatitis, nonalcoholic Laënnec's disease,diabetes hepatitis, alcohol-like liver disease, and nonalcoholicsteatohepatitis. Nonalcoholic fatty liver disease is becomingthe preferred term, and it refers to a wide spectrum of liverdamage, ranging from simple steatosis to steatohepatitis, advancedfibrosis, and cirrhosis. Steatohepatitis (nonalcoholic steatohepatitis)represents only a stage within the spectrum of . . . [Full Text of this Article]
Epidemiologic Features
Risk Factors
Prevalence
Clinical Manifestations
Clinical Features
Laboratory Abnormalities
Imaging Studies
Histologic Findings
Pathogenesis
Diagnosis
Role of Liver Biopsy
Natural History
Management
Associated Conditions
Drug Therapy
General Recommendations
Conclusions
Source Information
From the Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, Minn.
Address reprint requests to Dr. Angulo at the Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, 200 First St. SW, Rochester, MN 55905, or at angulohernandez.paul@mayo.edu.
References
Related Letters:
Nonalcoholic Fatty Liver Disease
Bode J. C., Inzucchi S. E., Petersen K. F., Shulman G. I., Babb R. R., Marignani M., Angeletti S., Angulo P.
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N Engl J Med 2002;
347:768-769, Sep 5, 2002.
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