Nonalcoholic fatty liver disease is an increasingly recognizedcondition that may progress to end-stage liver disease. Thepathological picture resembles that of alcohol-induced liverinjury, but it occurs in patients who do not abuse alcohol.1,2A variety of terms have been used to describe this entity, includingfatty-liver hepatitis, nonalcoholic Laënnec's disease,diabetes hepatitis, alcohol-like liver disease, and nonalcoholicsteatohepatitis. Nonalcoholic fatty liver disease is becomingthe preferred term, and it refers to a wide spectrum of liverdamage, ranging from simple steatosis to steatohepatitis, advancedfibrosis, and cirrhosis. Steatohepatitis (nonalcoholic steatohepatitis)represents only a stage within the spectrum of . . . [Full Text of this Article]
Epidemiologic Features
Risk Factors
Prevalence
Clinical Manifestations
Clinical Features
Laboratory Abnormalities
Imaging Studies
Histologic Findings
Pathogenesis
Diagnosis
Role of Liver Biopsy
Natural History
Management
Associated Conditions
Drug Therapy
General Recommendations
Conclusions
Source Information
From the Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, Minn.
Address reprint requests to Dr. Angulo at the Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, 200 First St. SW, Rochester, MN 55905, or at angulohernandez.paul@mayo.edu.
References
Related Letters:
Nonalcoholic Fatty Liver Disease
Bode J. C., Inzucchi S. E., Petersen K. F., Shulman G. I., Babb R. R., Marignani M., Angeletti S., Angulo P.
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347:768-769, Sep 5, 2002.
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194: 539-550
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Kumazawa, M., Kobayashi, M., Io, F., Kawai, T., Nishimura, M., Ohno, T., Horio, F.
(2007). Searching for genetic factors of fatty liver in SMXA-5 mice by quantitative trait loci analysis under a high-fat diet. J. Lipid Res.
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[Abstract][Full Text]
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[Abstract][Full Text]
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(2007). HGF ameliorates a high-fat diet-induced fatty liver. Am. J. Physiol. Gastrointest. Liver Physiol.
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293: E435-E442
[Abstract][Full Text]
Jakobsen, M., Berentzen, T, Sorensen, T., Overvad, K
(2007). Abdominal Obesity and Fatty Liver. Epidemiol Rev
0: mxm002v1-
[Abstract][Full Text]
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292: G1385-G1395
[Abstract][Full Text]
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[Abstract]
Chang, Y., Ryu, S., Sung, E., Jang, Y.
(2007). Higher Concentrations of Alanine Aminotransferase within the Reference Interval Predict Nonalcoholic Fatty Liver Disease. Clin. Chem.
53: 686-692
[Abstract][Full Text]
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[Full Text]
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(2007). Weight loss induced by orlistat reverses fatty infiltration and improves hepatic fibrosis in obese patients with non-alcoholic steatohepatitis. Gut
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30: 734-743
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Wang, Z., Xia, B., Ma, C., Hu, Z., Chen, X., Cao, P.
(2007). Prevalence and risk factors of fatty liver disease in the Shuiguohu district of Wuhan city, central China. Postgrad. Med. J.
83: 192-195
[Abstract][Full Text]
Saadeh, S.
(2007). Nonalcoholic Fatty Liver Disease and Obesity. Nutr Clin Pract
22: 1-10
[Abstract][Full Text]
Grundy, S. M.
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27: 4-7
[Full Text]
Fishman, S., Muzumdar, R. H., Atzmon, G., Ma, X., Yang, X., Einstein, F. H., Barzilai, N.
(2007). Resistance to leptin action is the major determinant of hepatic triglyceride accumulation in vivo. FASEB J.
21: 53-60
[Abstract][Full Text]
Bertolani, C., Sancho-Bru, P., Failli, P., Bataller, R., Aleffi, S., DeFranco, R., Mazzinghi, B., Romagnani, P., Milani, S., Gines, P., Colmenero, J., Parola, M., Gelmini, S., Tarquini, R., Laffi, G., Pinzani, M., Marra, F.
(2006). Resistin as an Intrahepatic Cytokine: Overexpression during Chronic Injury and Induction of Proinflammatory Actions in Hepatic Stellate Cells. Am. J. Pathol.
169: 2042-2053
[Abstract][Full Text]
Alwayn, I. P. J., Andersson, C., Lee, S., Arsenault, D. A., Bistrian, B. R., Gura, K. M., Nose, V., Zauscher, B., Moses, M., Puder, M.
(2006). Inhibition of matrix metalloproteinases increases PPAR-{alpha} and IL-6 and prevents dietary-induced hepatic steatosis and injury in a murine model. Am. J. Physiol. Gastrointest. Liver Physiol.
291: G1011-G1019
[Abstract][Full Text]
Nobili, V., Manco, M., Ciampalini, P., Diciommo, V., Devito, R., Piemonte, F., Comparcola, D., Guidi, R., Marcellini, M.
(2006). Leptin, free leptin index, insulin resistance and liver fibrosis in children with non-alcoholic fatty liver disease.. Eur J Endocrinol
155: 735-743
[Abstract][Full Text]
Baumann, U., Brown, R.
(2006). Review: Non-alcoholic fatty liver disease in childhood. British Journal of Diabetes & Vascular Disease
6: 264-268
[Abstract]
Burgert, T. S., Taksali, S. E., Dziura, J., Goodman, T. R., Yeckel, C. W., Papademetris, X., Constable, R. T., Weiss, R., Tamborlane, W. V., Savoye, M., Seyal, A. A., Caprio, S.
(2006). Alanine Aminotransferase Levels and Fatty Liver in Childhood Obesity: Associations with Insulin Resistance, Adiponectin, and Visceral Fat. J. Clin. Endocrinol. Metab.
91: 4287-4294
[Abstract][Full Text]
Hamer, O. W., Aguirre, D. A., Casola, G., Lavine, J. E., Woenckhaus, M., Sirlin, C. B.
(2006). Fatty Liver: Imaging Patterns and Pitfalls. RadioGraphics
26: 1637-1653
[Abstract][Full Text]
Dentin, R., Benhamed, F., Hainault, I., Fauveau, V., Foufelle, F., Dyck, J. R.B., Girard, J., Postic, C.
(2006). Liver-Specific Inhibition of ChREBP Improves Hepatic Steatosis and Insulin Resistance in ob/ob Mice.. Diabetes
55: 2159-2170
[Abstract][Full Text]
Lautamaki, R., Borra, R., Iozzo, P., Komu, M., Lehtimaki, T., Salmi, M., Jalkanen, S., Airaksinen, K. E. J., Knuuti, J., Parkkola, R., Nuutila, P.
(2006). Liver steatosis coexists with myocardial insulin resistance and coronary dysfunction in patients with type 2 diabetes. Am. J. Physiol. Endocrinol. Metab.
291: E282-E290
[Abstract][Full Text]
Wei, Y., Wang, D., Topczewski, F., Pagliassotti, M. J.
(2006). Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells. Am. J. Physiol. Endocrinol. Metab.
291: E275-E281
[Abstract][Full Text]
Carpentier, Y. A, Portois, L., Malaisse, W. J
(2006). n-3 Fatty acids and the metabolic syndrome. Am. J. Clin. Nutr.
83: S1499-1504S
[Abstract][Full Text]
Targher, G., Bertolini, L., Padovani, R., Rodella, S., Zoppini, G., Zenari, L., Cigolini, M., Falezza, G., Arcaro, G.
(2006). Relations Between Carotid Artery Wall Thickness and Liver Histology in Subjects With Nonalcoholic Fatty Liver Disease.. Diabetes Care
29: 1325-1330
[Abstract][Full Text]
Lin, X., Chen, Z., Yue, P., Averna, M. R., Ostlund, R. E. Jr., Watson, M. A., Schonfeld, G.
(2006). A targeted apoB38.9 mutation in mice is associated with reduced hepatic cholesterol synthesis and enhanced lipid peroxidation. Am. J. Physiol. Gastrointest. Liver Physiol.
290: G1170-G1176
[Abstract][Full Text]
Feldstein, A. E., Werneburg, N. W., Li, Z., Bronk, S. F., Gores, G. J.
(2006). Bax inhibition protects against free fatty acid-induced lysosomal permeabilization. Am. J. Physiol. Gastrointest. Liver Physiol.
290: G1339-G1346
[Abstract][Full Text]
Adams, L A, Angulo, P
(2006). Treatment of non-alcoholic fatty liver disease.. Postgrad. Med. J.
82: 315-322
[Abstract][Full Text]
Ortega, E., Koska, J., Salbe, A. D., Tataranni, P. A., Bunt, J. C.
(2006). Serum {gamma}-Glutamyl Transpeptidase Is a Determinant of Insulin Resistance Independently of Adiposity in Pima Indian Children. J. Clin. Endocrinol. Metab.
91: 1419-1422
[Abstract][Full Text]
Pagano, C., Soardo, G., Pilon, C., Milocco, C., Basan, L., Milan, G., Donnini, D., Faggian, D., Mussap, M., Plebani, M., Avellini, C., Federspil, G., Sechi, L. A., Vettor, R.
(2006). Increased Serum Resistin in Nonalcoholic Fatty Liver Disease Is Related to Liver Disease Severity and Not to Insulin Resistance. J. Clin. Endocrinol. Metab.
91: 1081-1086
[Abstract][Full Text]
Navarro, V. J., Senior, J. R.
(2006). Drug-Related Hepatotoxicity. NEJM
354: 731-739
[Full Text]
Wang, D., Wei, Y., Pagliassotti, M. J.
(2006). Saturated Fatty Acids Promote Endoplasmic Reticulum Stress and Liver Injury in Rats with Hepatic Steatosis. Endocrinology
147: 943-951
[Abstract][Full Text]
Targher, G., Bertolini, L., Padovani, R., Zoppini, G., Zenari, L., Falezza, G.
(2005). Letter to the Editor: Associations Between Liver Histology and Carotid Intima-Media Thickness in Patients With Nonalcoholic Fatty Liver Disease. Arterioscler. Thromb. Vasc. Bio.
25: 2687-2688
[Full Text]
Boden, G., She, P., Mozzoli, M., Cheung, P., Gumireddy, K., Reddy, P., Xiang, X., Luo, Z., Ruderman, N.
(2005). Free Fatty Acids Produce Insulin Resistance and Activate the Proinflammatory Nuclear Factor-{kappa}B Pathway in Rat Liver. Diabetes
54: 3458-3465
[Abstract][Full Text]
Targher, G., Bertolini, L., Poli, F., Rodella, S., Scala, L., Tessari, R., Zenari, L., Falezza, G.
(2005). Nonalcoholic Fatty Liver Disease and Risk of Future Cardiovascular Events Among Type 2 Diabetic Patients. Diabetes
54: 3541-3546
[Abstract][Full Text]
Hamaguchi, M., Kojima, T., Takeda, N., Nakagawa, T., Taniguchi, H., Fujii, K., Omatsu, T., Nakajima, T., Sarui, H., Shimazaki, M., Kato, T., Okuda, J., Ida, K.
(2005). The Metabolic Syndrome as a Predictor of Nonalcoholic Fatty Liver Disease. ANN INTERN MED
143: 722-728
[Abstract][Full Text]
Qayyum, A., Goh, J. S., Kakar, S., Yeh, B. M., Merriman, R. B., Coakley, F. V.
(2005). Accuracy of Liver Fat Quantification at MR Imaging: Comparison of Out-of-Phase Gradient-Echo and Fat-saturated Fast Spin-Echo Techniques--Initial Experience. Radiology
237: 507-511
[Abstract][Full Text]
Grefhorst, A., van Dijk, T. H., Hammer, A., van der Sluijs, F. H., Havinga, R., Havekes, L. M., Romijn, J. A., Groot, P. H., Reijngoud, D.-J., Kuipers, F.
(2005). Differential effects of pharmacological liver X receptor activation on hepatic and peripheral insulin sensitivity in lean and ob/ob mice. Am. J. Physiol. Endocrinol. Metab.
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[Abstract][Full Text]
Hamer, O. W., Aguirre, D. A., Casola, G., Sirlin, C. B.
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[Abstract][Full Text]
Aso, Y., Wakabayashi, S., Yamamoto, R., Matsutomo, R., Takebayashi, K., Inukai, T.
(2005). Metabolic Syndrome Accompanied by Hypercholesterolemia Is Strongly Associated With Proinflammatory State and Impairment of Fibrinolysis in Patients With Type 2 Diabetes: Synergistic effects of plasminogen activator inhibitor-1 and thrombin-activatable fibrinolysis inhibitor . Diabetes Care
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[Abstract][Full Text]
Grefhorst, A., Hoekstra, J., Derks, T. G. J., Ouwens, D. M., Baller, J. F. W., Havinga, R., Havekes, L. M., Romijn, J. A., Kuipers, F.
(2005). Acute hepatic steatosis in mice by blocking {beta}-oxidation does not reduce insulin sensitivity of very-low-density lipoprotein production. Am. J. Physiol. Gastrointest. Liver Physiol.
289: G592-G598
[Abstract][Full Text]
Sankatsing, R. R., Fouchier, S. W., de Haan, S., Hutten, B. A., de Groot, E., Kastelein, J. J.P., Stroes, E. S.G.
(2005). Hepatic and Cardiovascular Consequences of Familial Hypobetalipoproteinemia. Arterioscler. Thromb. Vasc. Bio.
25: 1979-1984
[Abstract][Full Text]
Targher, G., Brea, A., Ros, E.
(2005). Nonalcoholic Fatty Liver Disease and Atherosclerosis. Arterioscler. Thromb. Vasc. Bio.
25: e117-e118
[Full Text]
Stefan, N., Schafer, S., Machicao, F., Machann, J., Schick, F., Claussen, C. D., Stumvoll, M., Haring, H.-U., Fritsche, A.
(2005). Liver Fat and Insulin Resistance Are Independently Associated with the -514C>T Polymorphism of the Hepatic Lipase Gene. J. Clin. Endocrinol. Metab.
90: 4238-4243
[Abstract][Full Text]
Lin, X., Yue, P., Xie, Y., Davidson, N. O., Sakata, N., Ostlund, R. E. Jr., Chen, Z., Schonfeld, G.
(2005). Reduced intestinal fat absorptive capacity but enhanced susceptibility to diet-induced fatty liver in mice heterozygous for ApoB38.9 truncation. Am. J. Physiol. Gastrointest. Liver Physiol.
289: G146-G152
[Abstract][Full Text]
Bloomgarden, Z. T.
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28: 1518-1523
[Full Text]
Ding, X., Saxena, N. K., Lin, S., Xu, A., Srinivasan, S., Anania, F. A.
(2005). The Roles of Leptin and Adiponectin: A Novel Paradigm in Adipocytokine Regulation of Liver Fibrosis and Stellate Cell Biology. Am. J. Pathol.
166: 1655-1669
[Abstract][Full Text]
Lin, X., Yue, P., Chen, Z., Schonfeld, G.
(2005). Hepatic triglyceride contents are genetically determined in mice: results of a strain survey. Am. J. Physiol. Gastrointest. Liver Physiol.
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[Abstract][Full Text]
Sundaram, S. S., Whitington, P. F., Green, R. M.
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[Abstract][Full Text]
Schadinger, S. E., Bucher, N. L. R., Schreiber, B. M., Farmer, S. R.
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[Abstract][Full Text]
Yu, Y.-H., Ginsberg, H. N.
(2005). Adipocyte Signaling and Lipid Homeostasis: Sequelae of Insulin-Resistant Adipose Tissue. Circ. Res.
96: 1042-1052
[Abstract][Full Text]
Assy, N, Schlesinger, S, Hussein, O
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54: 729-729
[Full Text]
Brea, A., Mosquera, D., Martin, E., Arizti, A., Cordero, J. L., Ros, E.
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25: 1045-1050
[Abstract][Full Text]
Ackerman, Z., Oron-Herman, M., Grozovski, M., Rosenthal, T., Pappo, O., Link, G., Sela, B.-A.
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[Abstract][Full Text]
Barazzoni, R., Zanetti, M., Bosutti, A., Biolo, G., Vitali-Serdoz, L., Stebel, M., Guarnieri, G.
(2005). Moderate Caloric Restriction, But Not Physiological Hyperleptinemia Per Se, Enhances Mitochondrial Oxidative Capacity in Rat Liver and Skeletal Muscle--Tissue-Specific Impact on Tissue Triglyceride Content and AKT Activation. Endocrinology
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[Abstract][Full Text]
Adams, L. A., Angulo, P., Lindor, K. D.
(2005). Nonalcoholic fatty liver disease. CMAJ
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[Abstract][Full Text]
Angelico, F., Del Ben, M., Conti, R., Francioso, S., Feole, K., Fiorello, S., Cavallo, M. G., Zalunardo, B., Lirussi, F., Alessandri, C., Violi, F.
(2005). Insulin Resistance, the Metabolic Syndrome, and Nonalcoholic Fatty Liver Disease. J. Clin. Endocrinol. Metab.
90: 1578-1582
[Abstract][Full Text]
Szczepaniak, L. S., Nurenberg, P., Leonard, D., Browning, J. D., Reingold, J. S., Grundy, S., Hobbs, H. H., Dobbins, R. L.
(2005). Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Am. J. Physiol. Endocrinol. Metab.
288: E462-E468
[Abstract][Full Text]
Pagano, C., Soardo, G., Esposito, W., Fallo, F., Basan, L., Donnini, D., Federspil, G., Sechi, L. A, Vettor, R.
(2005). Plasma adiponectin is decreased in nonalcoholic fatty liver disease. Eur J Endocrinol
152: 113-118
[Abstract][Full Text]
Kerner, A., Avizohar, O., Sella, R., Bartha, P., Zinder, O., Markiewicz, W., Levy, Y., Brook, G. J., Aronson, D.
(2005). Association Between Elevated Liver Enzymes and C-Reactive Protein: Possible Hepatic Contribution to Systemic Inflammation in the Metabolic Syndrome. Arterioscler. Thromb. Vasc. Bio.
25: 193-197
[Abstract][Full Text]
Barazzoni, R., Bosutti, A., Stebel, M., Cattin, M. R., Roder, E., Visintin, L., Cattin, L., Biolo, G., Zanetti, M., Guarnieri, G.
(2005). Ghrelin regulates mitochondrial-lipid metabolism gene expression and tissue fat distribution in liver and skeletal muscle. Am. J. Physiol. Endocrinol. Metab.
288: E228-E235
[Abstract][Full Text]
Tolman, K. G., Fonseca, V., Tan, M. H., Dalpiaz, A.
(2004). Narrative Review: Hepatobiliary Disease in Type 2 Diabetes Mellitus. ANN INTERN MED
141: 946-956
[Abstract][Full Text]
Caterson, I. D., Hubbard, V., Bray, G. A., Grunstein, R., Hansen, B. C., Hong, Y., Labarthe, D., Seidell, J. C., Smith, S. C. Jr
(2004). Prevention Conference VII: Obesity, a Worldwide Epidemic Related to Heart Disease and Stroke: Group III: Worldwide Comorbidities of Obesity. Circulation
110: e476-e483
[Full Text]
Lecube, A., Hernandez, C., Genesca, J., Esteban, J. I., Jardi, R., Garcia, L., Simo, R.
(2004). Diabetes Is the Main Factor Accounting for the High Ferritin Levels Detected in Chronic Hepatitis C Virus Infection. Diabetes Care
27: 2669-2675
[Abstract][Full Text]
Sahai, A., Malladi, P., Pan, X., Paul, R., Melin-Aldana, H., Green, R. M., Whitington, P. F.
(2004). Obese and diabetic db/db mice develop marked liver fibrosis in a model of nonalcoholic steatohepatitis: role of short-form leptin receptors and osteopontin. Am. J. Physiol. Gastrointest. Liver Physiol.
287: G1035-G1043
[Abstract][Full Text]
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