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Volume 346:1326-1328 April 25, 2002 Number 17
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Clinical Investigation of Smallpox in 1767

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In 1767, William Watson was the physician for the Hospital for the Maintenance and Education of Exposed and Deserted Children, universally known as the Foundling Hospital, which was established in 1739 to provide a home for some of London's abandoned children. His practice was devoted entirely to the care and treatment of children accepted into this charitable establishment. At the time, the leading cause of death among children in London was smallpox. The infection was endemic and killed about one in four children born in the city. When the Foundling Hospital was opened, the board of governors recognized that because . . . [Full Text of this Article]

An Experimental Design

Interpreting Watson's Data

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Clinical Investigation in the 18th Century
Lepreau F. J., Boylston A. W.
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N Engl J Med 2002; 347:692, Aug 29, 2002. Correspondence

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