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Previous Volume 346:1399-1400 May 2, 2002 Number 18 Next

Anti–TNF- Therapy for Ankylosing Spondylitis — A Specific or Nonspecific Treatment?

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The spondyloarthropathies comprise ankylosing spondylitis, reactive arthritis, arthritis that accompanies inflammatory bowel disease, some forms of psoriatic arthritis, and undifferentiated forms of spondyloarthropathy. The report in this issue of the Journal by Gorman et al.¹ focuses on ankylosing spondylitis, a seronegative spondyloarthropathy that is associated with HLA-B27 in about 90 percent of patients. HLA-B27 has a role in the binding of antigenic peptides and in their presentation to CD8+ T cells. HLA-B27–restricted cytotoxic T cells with specificity for bacteria, viral peptides, or autoantigens that cause arthritis, such as peptides derived from the HLA-B27 molecule itself, have been identified in patients . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Pham, T, van der Heijde, D, Calin, A, Khan, M A, van der Linden, S., Bellamy, N, Dougados, M (2003). Initiation of biological agents in patients with ankylosing spondylitis: results of a Delphi study by the ASAS Group. Ann Rheum Dis 62: 812-816 [Abstract] [Full Text]  
• Mpofu, S., Teh, L. S., Smith, P. J., Moots, R. J., Hawkins, P. N. (2003). Cytostatic therapy for AA amyloidosis complicating psoriatic spondyloarthropathy. Rheumatology (Oxford) 42: 362-366 [Abstract] [Full Text]  
• van Roon, J A G, Bijlsma, J W J (2002). Th2 mediated regulation in RA and the spondyloarthropathies. Ann Rheum Dis 61: 951-954 [Full Text]