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Previous Volume 346:1410-1412 May 2, 2002 Number 18 Next

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To the Editor: Quaini and colleagues (Jan. 3 issue)¹ claim that stem cells of host origin are found in transplanted hearts. The authors identified host-derived cells within the transplanted organs on the basis of the detection of Y chromosomes in male recipients of female hearts. To establish the stem-cell nature of these cells, they used immunohistochemical studies to evaluate the expression of three molecules (c-kit, MDR1, and Sca-1) that have previously been used to identify hematopoietic stem cells in mice (Sca-1 and c-kit) and humans (MDR1 and c-kit).^2,3,4 As the authors indicate, none of these three molecules are unique to . . . [Full Text of this Article]

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