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Previous Volume 346:1415-1416 May 2, 2002 Number 18 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Several details in the review article on hereditary periodic fever (Dec. 13 issue)¹ warrant clarification. The authors state that the frequency of the susceptibility gene for familial Mediterranean fever is 1 in 135 among Ashkenazi Jews, a figure derived from population studies performed before the gene (MEFV ) was cloned. Since the advent of DNA analysis, we and others have reported a frequency of 1 in 5 among Ashkenazi Jews.^2,3,4 The discrepancy may be due in part to the high frequency of the E148Q mutation, which may be associated with mild disease or nonpenetrance. The authors . . . [Full Text of this Article]

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