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Previous Volume 346:1545-1552 May 16, 2002 Number 20 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Chimerism, the presence of two genetically distinct cell lines in an organism, either is acquired through the infusion of allogeneic hematopoietic cells during transplantation¹ or transfusion² or is inherited. In fraternal twins, chimerism occurs by means of blood-vessel anastomoses. A less common cause of congenital chimerism — so-called tetragametic chimerism — occurs through the fertilization of two ova by two spermatozoa, followed by the fusion of the zygotes and the development of an organism with intermingled cell lines.³ Examples have been found in mice⁴ and other mammalian species,^5,6,7 including humans.^{8,9,10,11,12,13,14,15,16,17} Affected persons are identified by the finding of two populations . . . [Full Text of this Article]

Case Report

Methods

Tissue Collection

Blood Grouping and HLA Studies

Cytogenetic Analysis

Determination of Sex Chromosomes

Short Tandem-Repeat Microsatellite Markers

Mixed-Lymphocyte Culture and Cell-Mediated Lysis

Results

Blood Typing

HLA Studies

Cytogenetic Analysis

Short Tandem-Repeat Microsatellite Markers

Mixed-Lymphocyte Culture and Cell-Mediated Lysis

Discussion

Source Information

From the American Red Cross Blood Services, New England Region, Dedham, Mass. (N.Y., S.A., M.O.); Beth Israel Deaconess Medical Center and Harvard Medical School, Boston (M.S.K., J.H.M.K., L.U.); Servicios Medicos Yunis Turbay, Bogota, Colombia (Juan J. Yunis, Emilio J. Yunis); Departamento de Patología, Facultad de Medicina e Instituto de Genética, Universidad Nacional, Bogota, Colombia (Juan J. Yunis); Dana–Farber Cancer Institute and Harvard Medical School, Boston (O.C., Z.H., Edmond J. Yunis); and Miami (Jorge J. Yunis).

Address reprint requests to Dr. Kruskall at the Division of Laboratory and Transfusion Medicine, Yamins 309, Beth Israel Deaconess Medical Center, 330 Brookline Ave., Boston, MA 02215, or at mkruskal@caregroup.harvard.edu.

References

This article has been cited by other articles:

• Lipsker, D., Flory, E., Wiesel, M.-L., Hanau, D., de la Salle, H. (2008). Between Light and Dark, the Chimera Comes Out. Arch Dermatol 144: 327-330 [Abstract] [Full Text]  
• Findlay, J.K., Gear, M.L., Illingworth, P.J., Junk, S.M., Kay, G., Mackerras, A.H., Pope, A., Rothenfluh, H.S., Wilton, L. (2007). Human embryo: a biological definition. Hum Reprod 22: 905-911 [Abstract] [Full Text]  
• Robinson, W. P., Lauzon, J. L., Innes, A.M., Lim, K., Arsovska, S., McFadden, D. E. (2007). Origin and outcome of pregnancies affected by androgenetic/biparental chimerism. Hum Reprod 22: 1114-1122 [Abstract] [Full Text]  
• Malan, V., Gesny, R., Morichon-Delvallez, N., Aubry, M.C., Benachi, A., Sanlaville, D., Turleau, C., Bonnefont, J.P., Fekete-Nihoul, C., Vekemans, M. (2007). Prenatal diagnosis and normal outcome of a 46,XX/46,XY chimera: A Case Report. Hum Reprod 22: 1037-1041 [Abstract] [Full Text]  
• Hird, M. J. (2007). The Corporeal Generosity of Maternity. Body Society 13: 1-20 [Abstract]  
• Boklage, C. E. (2006). Embryogenesis of chimeras, twins and anterior midline asymmetries. Hum Reprod 21: 579-591 [Abstract] [Full Text]  
• Turco, A E, Bambara, L M (2004). Pregnancy, microchimerism and autoimmunity: an update. Lupus 13: 659-660 [Abstract]  
• Hird, M. J. (2004). Chimerism, Mosaicism and the Cultural Construction of Kinship. Sexualities 7: 217-232 [Abstract]