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Previous Volume 346:1572-1574 May 16, 2002 Number 20 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Osteoporosis affects several million people and is associated with medical costs of up to $15 billion per year in the United States alone.^1,2 Thus, identifying the molecular mechanisms that control bone mass is a task of the utmost importance. The recent identification of the role of the low-density lipoprotein receptor–related protein 5 (LRP5) gene in the regulation of bone mass is a landmark discovery.^3,4,5,6 We examine the lock-and-key mechanism involving LRP5 that regulates two different functions: bone formation and vision.

The Lock

The low-density lipoprotein receptor–related proteins are a family of cell-surface receptors involved in diverse biologic processes, including lipid metabolism, retinoid . . . [Full Text of this Article]

The Key

Mechanism of Action of LRP5

Implications

References

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