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Previous Volume 346:1586-1588 May 16, 2002 Number 20 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Van den Berghe and colleagues (Nov. 8 issue)¹ report that intensive insulin therapy reduces mortality and morbidity among patients admitted to the surgical intensive care unit. Both the authors and Evans,² in the accompanying editorial, suggest that strict control of glycemia is the principal factor contributing to the improved outcomes reported. However, insulin might have had a role independent of its effect on glycemia.

Severely ill patients in intensive care units have a "cytokine storm" with release of tumor necrosis factor (TNF-) and macrophage inhibitory factor.³ TNF- is also released in acute myocardial infarction; it causes . . . [Full Text of this Article]

References

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• Oeyen, S. G., Hoste, E. A., Roosens, C. D., Decruyenaere, J. M., Blot, S. I. (2007). Adherence to and Efficacy and Safety of an Insulin Protocol in the Critically Ill: A Prospective Observational Study. Am J Crit Care 16: 599-608 [Abstract] [Full Text]  
• Carvalho, G., Moore, A., Qizilbash, B., Lachapelle, K., Schricker, T. (2004). Maintenance of Normoglycemia During Cardiac Surgery. Anesth. Analg. 99: 319-324 [Abstract] [Full Text]  
• Janes, K. A., Albeck, J. G., Peng, L. X., Sorger, P. K., Lauffenburger, D. A., Yaffe, M. B. (2003). A High-throughput Quantitative Multiplex Kinase Assay for Monitoring Information Flow in Signaling Networks: Application to Sepsis-Apoptosis. Mol. Cell. Proteomics 2: 463-473 [Abstract] [Full Text]