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Correspondence
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Volume 346:1591-1592 May 16, 2002 Number 20
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Overdose of Cyclic Antidepressants and the Brugada Syndrome

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To the Editor: The Brugada syndrome is a rare clinical and electrocardiographic entity consisting of sudden death from cardiac causes associated with right bundle-branch block and unusual ST-segment elevation in the right precordial leads (V1 to V3).1 A Brugada electrocardiographic pattern mimicked by overdose of cyclic antidepressants has been reported in rare instances.2 To assess the prevalence of the Brugada electrocardiographic pattern and its relation to death during overdose of cyclic antidepressants, a retrospective study was carried out in our intensive care unit.

We studied 98 consecutive cases of intoxication with cyclic antidepressants in 95 patients (mean [±SD] age, . . . [Full Text of this Article]

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