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Previous Volume 346:1667-1669 May 23, 2002 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: I would like to propose a hypothesis that may account for the findings of Borghi et al. (Jan. 10 issue).¹ The low-protein, low-salt diet they studied may have reduced the urinary monosodium urate concentration. An increase in urinary monosodium urate can promote the heterogeneous nucleation of calcium oxalate stones.² A low-sodium diet would reduce the relative concentration of urinary monosodium urate,³ and a low-protein diet would reduce the urinary uric acid concentration and increase the urinary citrate concentration.^4,5 Urinary citrate increases the solubility of uric acid and inhibits the formation of calcium oxalate stones. These considerations could . . . [Full Text of this Article]

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