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Volume 346:1723-1731 May 30, 2002 Number 22
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Cryptosporidiosis
Xian-Ming Chen, M.D., Janet S. Keithly, Ph.D., Carlos V. Paya, M.D., Ph.D., and Nicholas F. LaRusso, M.D.

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Cryptosporidiosis is caused by cryptosporidium, a parasite classified as an emerging pathogen by the Centers for Disease Control and Prevention (CDC).1 The organism infects the gastrointestinal epithelium to produce a diarrhea that is self-limited in immunocompetent persons but potentially life-threatening in immunocompromised persons, especially those with the acquired immunodeficiency syndrome (AIDS). Infection by this parasite accounts for up to 6 percent of all diarrheal disease in immunocompetent persons. The infection is also present in up to 24 percent of persons with both AIDS and diarrhea worldwide.1 A large water-borne outbreak in Milwaukee in 1993 affected an estimated 403,000 persons, 52 . . . [Full Text of this Article]

The Parasite

Epidemiologic Features

Immunologic Aspects

Pathophysiologic Features

Clinical Features

Diagnosis

Therapy

Prevention


Source Information

From the Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology (X.-M.C., N.F.L.), and the Division of Experimental Pathology (C.V.P.), Mayo Medical School, Clinic, and Foundation, Rochester, Minn.; and the Wadsworth Center, David Axelrod Institute, Albany, N.Y. (J.S.K.).

Address reprint requests to Dr. LaRusso at the Center for Basic Research in Digestive Diseases, Mayo Clinic, 200 First St., SW, Rochester, MN 55905, or at larusso.nicholas@mayo.edu.

References


Related Letters:

Cryptosporidiosis
Weber D. J., Rutala W. A.
Extract | Full Text | PDF  
N Engl J Med 2002; 347:1287, Oct 17, 2002. Correspondence

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